Quantifying the contribution of smear-negative, culture-positive pulmonary tuberculosis to nosocomial transmission

Yang, Ya-JenYa-JenYangSUNG-CHING PANMENG-RUI LEEChung, Che-LiangChe-LiangChungKu, Chia-PingChia-PingKuLiao, Chi-YuChi-YuLiaoTsai, Tien-YuTien-YuTsaiJANN-YUAN WANGCHI-TAI FANGYEE-CHUN CHEN2024-03-222024-03-222024-02-1501966553https://scholars.lib.ntu.edu.tw/handle/123456789/641245Despite current guidelines for tuberculosis (TB) control in health care settings, which focused on smear-positive cases, prevention of nosocomial TB transmission continues to be a challenge. Here, we report the results of the first hospital-wide prospective study applying interferon-gamma release assay to investigate the role of smear-negative, culture-positive index cases in nosocomial TB transmission.enAcid-fast smear; Aerosol-generating procedure; Contact investigation; Interferon-gamma releasing assay (IGRA); Latent tuberculosis infectionQuantifying the contribution of smear-negative, culture-positive pulmonary tuberculosis to nosocomial transmissionjournal article10.1016/j.ajic.2024.02.005383651782-s2.0-85186709231https://api.elsevier.com/content/abstract/scopus_id/85186709231