TONG-YUAN TAILouis, L HL HLouisQuade, M MM MQuade2023-05-312023-05-311979-070371-7682https://scholars.lib.ntu.edu.tw/handle/123456789/631648A modification of our published procedure for isolating a urinary diabetogenic polypeptide from diabetic patients with proteinuria has been applied to the urine of diabetic patients without proteinuria. The polypeptide obtained by this procedure was partially purified by chromatography on Biol-gel p-100 400 Mesh. The elution profile showed 3 major peaks. Diabetogenic activity was found in the first peak by means of glucose tolerance tests in dogs. Doses of 0.2-1.0 mg/kg of body weight induced glucose intolerance and glucosuria in dogs. Disc gel electrophoretic patterns of the partially purified polypeptide from proteinuric and non-proteinuric diabetic patients were similar. The polypeptide was also found in the urine of 11 healthy subjects but in much smaller quantities than in the diabetic patients.en[SDGs]SDG2journal article2916852-s2.0-0018490285https://api.elsevier.com/content/abstract/scopus_id/0018490285