Chen Y.-J.Chu W.-C.YEONG-SHIAU PUSHIH-CHIEH CHUEHCHIA-TUNG SHUNWEN-YIH TSENG2020-03-032020-03-0320121053-1807https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866396440&doi=10.1002%2fjmri.23723&partnerID=40&md5=a0e6e166161c4eeb40c5369d8d7d3787https://scholars.lib.ntu.edu.tw/handle/123456789/468745Purpose: To investigate the associations between dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) parameters and the Gleason score (GS) for prostate cancer (PCA) with localization information provided by concurrent apparent diffusion coefficient (ADC) maps. Materials and Methods: Forty-three male patients received MR scans, including diffusion tensor imaging (DTI) and DCE MRI, on a 1.5 T MR system. All patients were confirmed to have PCA in the following biopsy within 2 weeks. ADC maps calculated from DTI were used to colocalize cancerous and noncancerous regions on DCE MRI for perfusion analysis retrospectively. Semiquantitative parameters (peak enhancement, initial gradient, and washout gradient [WG] and quantitative parameters [K trans, νe, and kep]) were calculated and correlated with the GS. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of the perfusion parameters in assessing the aggressiveness of PCA. Results: A total of 41 PCA nodules were included in the analysis. Among all quantitative and semiquantitative parameters, only WG showed significant correlation with GS (r = -0.75, P < 0.0001). By defining tumor aggressiveness as a GS >6, WG demonstrated a good diagnostic performance, with the area under the ROC curve being 0.88. Under a cutoff point of WG = 0.125 min-1, the sensitivity and specificity were 0.87 and 0.78, respectively. Conclusion: WG shows a significant association with GS and good diagnostic performance in assessing tumor aggressiveness. Therefore, WG is a potential marker of GS. ? 2012 Wiley Periodicals, Inc.[SDGs]SDG3contrast medium; gadolinium pentetate; scopolamine butyl bromide; adult; aged; apparent diffusion coefficient; article; cancer localization; cancer patient; cancer tissue; clinical article; clinical assessment; contrast enhancement; controlled study; density gradient; diagnostic accuracy; diagnostic test accuracy study; diffusion coefficient; diffusion tensor imaging; disease severity; dynamic contrast enhanced magnetic resonance imaging; echography; Gleason score; human; male; nuclear magnetic resonance imaging; nuclear magnetic resonance scanner; pathophysiology; perfusion; predictive value; priority journal; prostate biopsy; prostate cancer; quantitative analysis; receiver operating characteristic; retrospective study; sensitivity and specificity; washout gradient; Aged; Algorithms; Contrast Media; Gadolinium DTPA; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Invasiveness; Prostatic Neoplasms; Reproducibility of Results; Sensitivity and Specificityjournal article10.1002/jmri.23723227114152-s2.0-84866396440