Hsueh Y.-M.Wu W.-L.Huang Y.-L.Chiou H.-Y.CHIN-HSIAO TSENGChen C.-J.2020-06-012020-06-0119980021-9150https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032403039&doi=10.1016%2fS0021-9150%2898%2900178-6&partnerID=40&md5=9324986031065ca34f7b3e576e75da1chttps://scholars.lib.ntu.edu.tw/handle/123456789/496233To elucidate the association between arsenic-related ischemic heart disease (ISHD) and serum antioxidant micronutrient level, residents aged 30 or older living in arseniasis-hyperendemic villages in Taiwan were recruited in a community-based health survey. A structured questionnaire was used to obtain a history of long-term exposure to arsenic through consuming artesian well water and fasting serum samples were also collected at the recruitment. A total of 74 patients affected with ISHD, who were diagnosed through both electrocardiography and Rose questionnaire interview, and 193 age-sex- matched healthy controls were selected for the examination of serum levels of micronutrients by high performance liquid chromatography (HPLC). There was a significant biological gradient between the risk of ISHD and the duration of consuming high-arsenic artesian well water. A significant reverse dose- response relationship with arsenic-related ISHD was observed for serum level of α- and β-carotene, but not for serum levels of retinol, lycopene and α- tocopherol. Multivariate analysis showed a synergistic interaction on arsenic-related ISHD between duration of consuming artesian well water and low serum carotene level. An increased risk of arsenic-related ISHD was also associated with hypertension and elevated body mass index, but not with serum lipid profile, cigarette smoking and alcohol drinking. The findings seem to suggest that arsenic-related ISHD has a pathogenic mechanism which is at least partially different from that of ISHD unrelated to long-term exposure to arsenic.[SDGs]SDG3arsenic; carotene; well water; alcohol consumption; article; blood sampling; body mass; cigarette smoking; fluid intake; high performance liquid chromatography; human; human cell; ischemic heart disease; long term exposure; malignant transformation; priority journal; risk assessment; risk factor; taiwan; Adult; Alcohol Drinking; Antioxidants; Arsenic; beta Carotene; Carotenoids; Chromatography, High Pressure Liquid; Humans; Multivariate Analysis; Myocardial Ischemia; Questionnaires; Risk Factors; Smoking; Socioeconomic Factors; Taiwan; Time Factors; Vitamin A; Vitamin E; Water Supplyjournal article10.1016/S0021-9150(98)00178-698621732-s2.0-0032403039