OWEN Y. CHAOWang, An-LiAn-LiWangNikolaus, SusanneSusanneNikolausde Souza Silva, Maria A.Maria A.de Souza Silva2025-09-052025-09-052015-0501664328https://www.scopus.com/inward/record.uri?eid=2-s2.0-84939881795&doi=10.1016%2Fj.bbr.2014.06.006&partnerID=40&md5=64c28155efa26f7a6b635a878f774417https://scholars.lib.ntu.edu.tw/handle/123456789/731854Animals treated with unilateral 6-hydroxydopamine (6-ODHA) injections, an animal model of Parkinson's disease, exhibit deficits in memory for temporal order, but show intact novel object recognition. Since senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in the aged rat and to alleviate scopolamine-induced impairment, the present study aimed to assess possible promnestic effects of senktide in the hemiparkinsonian rat model. Animals received unilateral 6-ODHA microinjections into the medial forebrain bundle. Two weeks later, they were randomly assigned to treatment with vehicle, 0.2, or 0.4 mg/kg senktide. Temporal order memory and place recognition tests were conducted, locomotor activity and turning behavior were assessed in the open field and anxiety-related behavior was measured in the light-dark box. Treatments were administered 30 min prior to behavioral testing with an interval of seven days between tests. The animals treated with 0.2 mg/kg senktide exhibited temporal order memory, unlike the vehicle-treated group. No significant treatment effects were found in the open field and light-dark box. Administration of 0.2 mg/kg senktide may influence the prefrontal cortex and hippocampus, leading to compensations for deficits in memory for temporal order.enfalse6-OHDANK(3) receptorParkinson's diseaseSenktideTemporal order memoryjournal article10.1016/j.bbr.2014.06.006249287702-s2.0-84939881795