鄭素芳2006-07-262018-07-082006-07-262018-07-082001http://ntur.lib.ntu.edu.tw//handle/246246/25606The purpose of this study was to compare the age of walking attainment between very Iow-birthweight (VLBW) preterm infants and normal term infants, and to determine the variables that affect the walking attainment in VLBW infants. Ninety-six VLBW preterm infants and 82 normal term infants were prospectively followed to determine their age of walking attainment and to monitor gross motor development with sequential clinic visits at 6, 9, 12 and 18 months corrected age. Perinatal and sociodemographic data were collected through review of medical records. The VLBW infants were significantly older at attainment of walking (median 14 months) than the term infants (median 12 months) after correction for prematurity. By the age of iS months, all term infants had attained walking ability; while 11% of VLBW infants were still unable to walk. Multivariate proportional hazards regression analysis revealed that low gestational age was significantly associated with late attainment of walking in VLBW infants. With the adjustment for gestational age, prolonged ventilation (or oxygen therapy) and severe retinopathy of prematurity were significant predictors of late walking attainment. Our findings indicate that VLBW preterm infants have an increased risk of delayed attainment of walking. Furthermore, the contribution of low gestational age to the delayed walking attainment in VLBW infants may occur via the plausible pathways of neonatal respiratory distress and severe retinopathy of prematurity.本研究的目的在比較極低體重早產充與正常足月兒獨立行走達成年齡，並探討影響早產兒獨立行走達成的可能因子參與的受試者為96 位極低體重早產兒與82 位正常足月兒，在矯正年齡6 、9 、12 及18 個月大時到院檢查，本研究以前瞻性追蹤的方式確定其行走達成的年齡並追蹤記錄嬰兒的粗動作發展，再依病歷搜集嬰兒出生資料與家庭社經地位等資料，極低體重早產兒的行走達成年糾中位數為14 個月顯著的晚於正常足月兒＜中位數為12 個月＞, 18 個月大時，所有正常足月兒已達成獨立行走，然而仍有百分之十一的極低體重早產兒還未達成獨立行走。根據多變項迴歸分析，極低體重早產兒的低懷孕週數和行走達成的遲緩有顯著相關。除了低懷孕週數外，長期使用呼吸器或用氣，以及嚴重早產兒視網膜病變亦與行走達成遲緩明顯相關。本研究發現：極低龍重早產兒易發生行走達成遲緩，此外，低懷孕週數所造成的行走達成遲緩可能來自於新生兒呼吸窘迫和嚴重早產兒視網膜病變兩個可能的途徑。application/pdf223582 bytesapplication/pdfzh-TW國立臺灣大學醫學院物理治療學系暨研究所Motor developmentPrematurityRisk factorWalking動作發展早產危險因子行走journal articlehttp://ntur.lib.ntu.edu.tw/bitstream/246246/25606/1/892314B002541.pdf