流行病學研究所;Graduate Institute of EpidemiologyLU, SHENG-NANSHENG-NANLUSU, WEI-WENWEI-WENSUYANG, SHENG-SHUNSHENG-SHUNYANGCHANG, TING-TSUNGTING-TSUNGCHANGCHENG, KEN-SHENGKEN-SHENGCHENGWU, JAW-CHINGJAW-CHINGWULIN, HANS, HSIEN-HONGHANS, HSIEN-HONGLINWU, SHUN-SHENGSHUN-SHENGWULEE, CHUAN-MOCHUAN-MOLEECHANGCHIEN, CHI-SINCHI-SINCHANGCHIENCHEN, CHIEN-JENCHIEN-JENCHENSHEU, JIN-CHUANJIN-CHUANSHEUCHEN, DING-SHINNDING-SHINNCHEN2008-10-032018-06-292008-10-032018-06-292006http://ntur.lib.ntu.edu.tw//handle/246246/82059Etiological variations in hepatocellular carcinoma (HCC) exist across different geographic areas. To gain better control of HCC, we retrospectively studied the secular trends and geographic variations in hepatitis B virus (HBV)- related and hepatitis C virus (HCV)-related HCCs in Taiwan. A total of 18,423 HCC cases enrolled in 8 medical centers from 1981 to 2001 were reviewed. Overall, 67% of male HCC in Taiwan was related to HBV infection whereas 55.2% of female HCC in Taiwan was related to HCV infection. The mean age of patients with HBV-related HCC was 53.2 +/- 13.6 years, while the mean age of patients with HCV-related HCC was 65.1 +/- 9.1 years (p < 0.001). The male/female ratio was 6.4 for HBV-related HCC, while it was 1.7 for the HCV-related HCC ( p < 0.001). The percentage of HBV-related HCC progressively decreased from 81.5 to 66.2% in males, and from 66.7 to 41. 4% in females over the study period. Our study demonstrates that the percentage of HBV-related HCC has progressively decreased over the last 20 years. The relative decrease in HBV-related HCC was not due to a decrease in HBV-related HCC death. Instead, it was caused by an increase in HCV-related HCC. Prevention of new HCV infection and the treatment of chronic hepatitis C should be the primary goals, which will result in better control of HCC in the future, even in an HBV-endemic area like Taiwan.( c) 2006 Wiley-Liss, Inc.en-UShepatocellular carcinomahepatitis B virushepatitis C virussecular trendgeographic variationTaiwan[SDGs]SDG3journal article