Lee S.-Y.MING-JIUM SHIEH2020-02-272020-02-272016https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988946218&partnerID=40&md5=47f2f1e89099f9f07aa7b0dc766ec050https://scholars.lib.ntu.edu.tw/handle/123456789/465737In the present study, we established a multifunctional gold nanoshell (GNS) that utilizing positively charged PDMA-b-PCL micelles as a template. By growing the gold layer on the surface of micelles, this newly synthesized GNS with micellar core enable the delivery of hydrophobic chemotherapeutics. The synthesized SN-38@pGNS had a spherical morphology and a narrow size distribution. With the exposure to NIR laser irradiation, SN-38@pGNS exhibited an excellent photothermal conversion efficiency. Moreover, the combination of chemotherapy and photothermal therapy resulted in a significant anticancer effect in the in vitro study. These results suggested the gold nanoshells with micellar core can serve as not only a photothermal mediator but also a delivery system for hydrophobic drugs. Therefore, the synthesized gold nanoshells with micellar core can be applied as a potential multifunctional therapeutics for cancer therapy in the future.Chemotherapy; Gold nanoshell; Micelles; Photothermal therapy; SN-38[SDGs]SDG3Chemotherapy; Diseases; Gold; Hydrophobicity; Micelles; Nanostructured materials; Nanostructures; Anticancer effects; Cancer photothermal therapies; Gold nanoshells; Narrow size distributions; NIR laser irradiation; Photothermal conversion efficiencies; Photothermal therapy; Spherical morphologies; Nanoshellsconference paper2-s2.0-84988946218