Integration of aerobic oxidation and intramolecular asymmetric aza-Friedel–Crafts reactions with a chiral bifunctional heterogeneous catalyst

Hong-Gang ChengJavier MiguélezHiroyuki MiyamuraWoo-Jin YooShū Kobayashi2020-02-142020-02-1420172041-65202041-6539https://scholars.lib.ntu.edu.tw/handle/123456789/458760© The Royal Society of Chemistry. A new class of chiral bifunctional heterogeneous materials composed of Au/Pd nanoparticles and chiral phosphoric acids as active orthogonal catalysts was prepared by utilizing a facile pseudo-suspension co-polymerization method. It was found that this heterogeneous catalyst was capable of facilitating the sequential aerobic oxidation-asymmetric intramolecular aza-Friedel-Crafts reaction between benzyl alcohols and N-aminoethylpyrroles. Moreover, the designed chiral heterogeneous catalyst could be recovered and reused several times without significant loss of activity or enantioselectivity.Integration of aerobic oxidation and intramolecular asymmetric aza-Friedel–Crafts reactions with a chiral bifunctional heterogeneous catalystjournal article10.1039/C6SC03849B689385212-s2.0-85010987118WOS:000395428300061https://publons.com/publon/6918254/68938521