Chang M.-C.BEI-EN CHANGPan Y.-H.Lian Y.-C.BOR-RU LINMING-SHU LEEYeung S.-Y.LI-DEH LINJIIANG-HUEI JENG2021-02-022021-02-0220190021-9541https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062724426&doi=10.1002%2fjcp.28444&partnerID=40&md5=65579eb4f8102edd6891cefc7e91ddaehttps://scholars.lib.ntu.edu.tw/handle/123456789/545879Platelets play crucial roles in thrombosis and hemostasis through platelet activation and aggregation that are crucial in cardiovascular diseases. Hydroquinone (HQ) and its derivatives are present in many dermatological creams, paints, motor fuels, air, microorganisms, and plant products like wheat bread, fruit, coffee, and red wine. The effect of HQ on humans is not clear. In this study, we found that HQ (>25 μM) inhibited arachidonic acid (AA)-induced platelet aggregation. HQ suppressed AA-induced thromboxane B2 production of platelets. HQ (>10 μM) also attenuated ex vivo platelet-rich plasma aggregation. HQ prevented the interleukin (IL)-1β-induced 8-isoprostane, and PGE2 production, but not IL-8 production of pulp cells. These results indicate that HQ may have an antiplatelet effect via inhibition of thromboxane production. HQ has antioxidative and anti-inflammatory effects, and possible inhibition of COX. Exposure and consumption of HQ-containing products, food or drugs may have antiplatelet, antioxidative, and anti-inflammatory effects. ? 2019 Wiley Periodicals, Inc.[SDGs]SDG3antiinflammatory agent; antioxidant; antithrombocytic agent; arachidonic acid; cyclooxygenase 2; glyceraldehyde 3 phosphate dehydrogenase; hydroquinone; interleukin 1beta; interleukin 8; isoprostane derivative; prostaglandin E2; thromboxane; thromboxane B2; 8-epi-prostaglandin F2alpha; antiinflammatory agent; antioxidant; antithrombocytic agent; autacoid; CXCL8 protein, human; cyclooxygenase 2; hydroquinone; hydroquinone derivative; interleukin 8; prostaglandin F2 alpha; PTGS2 protein, human; thromboxane A2; animal cell; animal experiment; antiinflammatory activity; antioxidant activity; antiplatelet activity; Article; bread; cardiovascular system; coffee; cream; cytotoxicity; drug use; enzyme linked immunosorbent assay; ex vivo study; food intake; fruit; IC50; mouse; nonhuman; plant product; platelet aggregation assay; priority journal; protein expression; red wine; thrombocyte; thrombocyte aggregation; thrombocyte function; thrombocyte rich plasma; tooth pulp; Western blotting; wheat; animal; cell culture; cytology; drug effect; human; Leporidae; metabolism; signal transduction; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Platelets; Cells, Cultured; Cyclooxygenase 2; Dental Pulp; Dinoprost; Dinoprostone; Humans; Hydroquinones; Inflammation Mediators; Interleukin-8; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Signal Transduction; Thromboxane A2journal article10.1002/jcp.28444308432192-s2.0-85062724426