2016-01-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/682267摘要：磷脂質是含磷酸基的脂質，同時具親水及疏水兩種基團，是人體內最重要的界面活性劑，也是細胞膜的主要成分。過去的研究通常探討磷脂質在溶液或雙層膜中的自組裝特性與應用，本研究則是計畫將磷脂質製成奈米纖維與具規整奈米結構的薄膜，並發展調控其微結構的有效方法。磷脂質是一種小分子，一般而言不易電紡成絲，然本實驗室過去所發展的磷脂質蟲狀微胞溶液因具備類似高分子溶液性質，為磷脂質電紡提供了一個解決方案。我們將利用電紡技術製備磷脂質奈米纖維，並探討纖維結構與蟲狀微胞溶液流變性質的關係。磷脂質所製成的纖維在生醫方面將有廣泛的應用潛力。另外，磷脂質的親水與疏水基團具高度不相容性，在塊材或薄膜中將類似團聯共聚物相分離成不同的區塊，因其分子量均一且遠小於團聯共聚物，其所形成的結構將非常規整且尺寸將大幅縮小(＜3 nm)，這將突破現有技術所達到的尺度。我們將利用旋轉塗佈技術製備磷脂質薄膜，調控其微結構如層狀或柱狀等，並發展控制方向性的技術，如何提高薄膜的機械強度也是研究重點之一。這類薄膜將可應用於奈米模板與微影蝕刻技術。<br> Abstract: Phosphatidylcholines are a class of amphiphilic lipids, consisting of hydrophobic tails and a hydrophilic head, and are a major component of cell membranes. Previous studies mostly focused on the self-assembled behaviors and applications of phosphatidylcholines in solutions or bilayer membranes. In the project, we propose to fabricate phosphatidylcholines into nanofibers and thin films with ordered nanostructures, and develop effective methods to tailor their morphologies. In general, it is a challenge to electrospin small molecules like phosphatidylcholines. Recently, we have developed phosphatidylcholine-based wormlike micellar solutions with flow properties similar to polymer solutions, which provide a means for phosphatidylcholines to be electrospun. We will produce phosphatidylcholine (lecithin) nanofibers using electrospinning techniques and investigate the relationship between fiber structures and the rheological properties of wormlike micellar solutions. Such fibers will be potential for biomedical applications. Moreover, the hydrophobic tails and hydrophilic heads of phosphatidylcholines are highly incompatible and thus, similar to block copolymers, they will phase separate into microdomains in bulk or in thin films. Due to the uniform molecular weight and much shorter molecular lengths, the microdomains formed by phosphatidyl- cholines will be highly ordered and extremely small in size (< 3 nm), the smallest ever reported. We will spin-cast phosphatidylcholines into thin films and manipulate their structures, such as lamellae and cylinders, and develop methods to control the orientation of the microdomains and to improve the mechanical properties of the films. Such films can be used in templates and lithographic applications.磷脂質電紡技術奈米纖維薄膜phosphatidylcholineelectrospinningnanofiberthin film