Tsai M.-S.Chou S.-E.HONG-SHIEE LAIJeng L.-B.Lin C.-L.Kao C.-H.2020-02-242020-02-2420150025-7974https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926337992&doi=10.1097%2fMD.0000000000000610&partnerID=40&md5=1abff10d8f5730c074914a22e3256467https://scholars.lib.ntu.edu.tw/handle/123456789/462364We aimed to assess the magnitude and duration of risk of acute coronary syndrome (ACS) associated with splenectomy for splenic injury. We identified 5139 splenectomized patients (the splenectomy cohort) to compare with 2 other cohorts for assessing the magnitude and risk of ACS: the first cohort comprising subjects without splenic injury and without splenectomy (control cohort), and the second cohort comprising nonsplenectomized patients with splenic injury (nonsplenectomy cohort; n=6391). For each splenic injury patient (n=11530), 4 control comparisons were frequency-matched by the year of index date, age, and sex (n=46120). The adjusted risk of ACS was significantly higher in the splenectomy group than in the control group (2.08 vs 1.68 per 1000 person-years; adjusted hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.01-1.68). The sex-specific data showed that the adjusted HR for the splenectomy group, compared with the control group, was 1.29 in men (95% CI, 0.97-1.73) and 1.36 in women (95% CI, 0.79-2.33). The age-specific analyses failed to demonstrate a significantly higher adjusted HR of ACS in the splenectomized patients in any age subgroup, compared with their counterparts in the control group. Furthermore, no difference in the risk of ACS was detected between the splenectomy and nonsplenectomy cohorts within the splenic injury patients. In comparison with the control cohort, patients undergoing splenectomy for splenic injury exhibited an elevated risk of ACS. Copyright ? 2015 Wolters Kluwer Health, Inc. All rights reserved.[SDGs]SDG3acute coronary syndrome; adult; aged; Article; cardiovascular risk; cerebrovascular accident; chronic obstructive lung disease; comorbidity; controlled study; diabetes mellitus; female; follow up; heart failure; human; hyperlipidemia; hypertension; ischemic heart disease; major clinical study; male; menopause; priority journal; spleen injury; splenectomy; acute coronary syndrome; age; incidence; injuries; middle aged; retrospective study; risk assessment; sex difference; spleen; splenectomy; statistics and numerical data; Acute Coronary Syndrome; Age Factors; Aged; Comorbidity; Female; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Risk Assessment; Sex Factors; Spleen; Splenectomyjournal article10.1097/MD.0000000000000610257384852-s2.0-84926337992