Shi, Yeu-ChingYeu-ChingShiTZU-MING PANShi, YCYCShiPan, Tzu-MingTzu-MingPanPan, TM.TM.Pan2018-09-102018-09-102012http://www.scopus.com/inward/record.url?eid=2-s2.0-84858440653&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/369430Type 2 diabetes is a major health concern and a rapidly growing disease with a modern etiology, which produces significant morbidity and mortality. The optimal management of type 2 diabetes aims to control hyperglycemia, hypertension, and dyslipidemia to reduce overall risks. Diabetes and its complications usually develop as oxidative stress increases. Monascus-fermented rice, also called red mold rice or red mold dioscorea are used in China to enhance food color and flavor. Red mold-fermented products are popular health foods that are considered to have antiobesity, antifatigue, antioxidation, and cancer prevention effects. This review article describes the antidiabetic and antioxidative stress effects on humans and animals of red mold-fermented products or their secondary metabolites. ? 2012 Springer-Verlag.Diabetes; Monascus; Oxidative stress; Red mold; Secondary metabolite[SDGs]SDG3Anti-fatigue; Anti-oxidation; Anti-oxidative stress; Antidiabetic; Cancer prevention; Dyslipidemias; Food colors; Health concerns; Health foods; Monascus; Optimal management; Secondary metabolites; Type-2 diabetes; Animals; Diseases; Health risks; Medical problems; Metabolites; Oxidative stress; Molds; 4 aminobutyric acid; advanced glycation end product; cholestin; citrinin; drug metabolite; flavoring agent; glucose; hexosamine; mevinolin; monascin; protein kinase C; unclassified drug; xuezhikang; cancer; color; diabetes; etiology; health risk; literature review; morbidity; mortality; oxidation; public health; rice; secondary metabolite; Alzheimer disease; antidiabetic activity; antioxidant activity; atherosclerosis; autoimmune disease; cardiomyopathy; cardiovascular disease; diabetes mellitus; diabetic hypertension; diabetic nephropathy; drug safety; endothelial dysfunction; fermented product; food color; gluconeogenesis; glucose blood level; glucose homeostasis; human; hyperglycemia; hyperinsulinemia; hyperlipidemia; hypertension; insulin blood level; insulin dependent diabetes mellitus; insulin resistance; Monascus; Monascus pilosus; Monascus purpureus; mould; non insulin dependent diabetes mellitus; nonhuman; oxidative stress; pancreas islet beta cell; retinopathy; review; rheumatoid arthritis; signal transduction; streptozocin diabetes; Animals; Antioxidants; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Monascus; Oryza sativa; Oxidative Stress; China; Animalia; Dioscorea; Monascusjournal article10.1007/s00253-012-3957-8