Chua H.-H.TE-HUEI YEHWang Y.-P.Sheen T.-S.Shew J.-Y.Huang Y.-T.CHING-HWA TSAI2022-01-192022-01-1920081043-3074https://www.scopus.com/inward/record.uri?eid=2-s2.0-57349194636&doi=10.1002%2fhed.20896&partnerID=40&md5=ee64ac6020228f360f24cc2d7e420ad6https://scholars.lib.ntu.edu.tw/handle/123456789/592684Background. Inhibitors of apoptosis proteins (IAPs), which counteract apoptosis by potently inhibiting caspase activation, are promising targets of new anti-tumor therapy. However, their roles in the pathogenesis of nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-associated carcinoma, are not fully understood. Herein, we investigated the expression and regulation of IAPs in NPC. Methods and Results. Using real-time quantitative polymerase chain reaction (PCR) analysis, we found that among the IAPs family only the transcription of survivin, HIAP-1, and HIAP-2 was consistently up-regulated in NPC and metastatic NPC tissues. Immunohistochemical staining showed that their proteins were more predominantly expressed in tumor cells nests. Noteworthy, these IAPs were upregulated by interleukin-1α stimulation or EBV infection, and subsequently resulted in triggering rapid proliferation of NPC verified by strong Ki-67 staining. Conclusion. Survivin, HIAP-1, and HIAP-2 were distinctly upregulated in NPC, suggesting they may play significant roles in NPC tumorigenesis and serve as tumor markers with prognostic and therapeutic implications. ? 2008 Wiley Periodicals, Inc.[SDGs]SDG3inhibitor of apoptosis protein 1; inhibitor of apoptosis protein 2; interleukin 1alpha; Ki 67 antigen; survivin; apoptosis; article; carcinogenesis; cell proliferation; clinical article; controlled study; disease marker; Epstein Barr virus; gene control; genetic transcription; human; human tissue; immunohistochemistry; metastasis; nasopharynx carcinoma; pathogenesis; priority journal; prognosis; protein expression; reverse transcription polymerase chain reaction; upregulation; Apoptosis; Carcinoma, Squamous Cell; Caspases; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Inhibitor of Apoptosis Proteins; Interleukin-1alpha; Microtubule-Associated Proteins; Nasopharyngeal Neoplasms; Polymerase Chain Reaction; Tumor Markers, Biologicaljournal article10.1002/hed.20896187983032-s2.0-57349194636