TUNG-HUNG SULiao C.-HCHEN-HUA LIUKAI-WEN HUANGTAI-CHUNG TSENGHUNG-CHIH YANGCHUN-JEN LIUPEI-JER CHENDING-SHINN CHENJIA-HORNG KAO2020-06-192020-06-1920180033-8419https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050258383&doi=10.1148%2fradiol.2018171116&partnerID=40&md5=9b9f2c1d4d03b3888a3d49dc099acf2ahttps://scholars.lib.ntu.edu.tw/handle/123456789/503604Purpose: To investigate the clinical utility and longitudinal change of acoustic radiation force impulse (ARFI) ultrasonographic (US) imaging in patients with chronic hepatitis B. Materials and Methods: A retrospective cohort study of patients with chronic hepatitis B who underwent serial ARFI examinations in a tertiary referral center in Taiwan between 2012 and 2016 was conducted. The clinical information and noninvasive liver stifness measurement tests (ARFI, Fibrosis-4 index [FIB-4], and FibroScan) were collected. Serial ARFI measurements were compared in patients without antiviral therapy (nontreatment group) and during antiviral therapy (treatment group). The linear mixed-effects model with random coefficients was used to compare longitudinal repeated measurements. Results: A total of 559 patients undergoing serial ARFI examinations were included. The ARFI value correlated with FIB-4 (correlation coefficient = 0.55, P < .001) and FibroScan (correlation coefficient = 0.69, P < .001) results. There were 314 patients with five or more ARFI measurements in more than 3 years of follow-up. The ARFI value remained unchanged in the nontreatment group (n = 189, from 1.11 to 1.11 m/sec, time trend P = .911). However, the ARFI value declined significantly in the treatment group (n = 125, from 1.63 to 1.37 m/sec, time trend P < .001), both in patients with cirrhosis (n = 51, from 2.15 to 1.75 m/sec, time trend P < .001) and in those without (n = 74, from 1.27 to 1.11 m/sec, time trend P < .001). Conclusion: ARFI US imaging is an important clinical noninvasive test for liver stifness measurement and can be used for serial measurements in the management of chronic hepatitis B. Antiviral therapy significantly reduces liver stifness during longitudinal follow-up. ? RSNA, 2018.[SDGs]SDG3antivirus agent; antivirus agent; acoustic radiation force impulse ultrasonographic imaging; adult; aged; antiviral therapy; Article; chronic hepatitis B; cohort analysis; controlled study; echography; female; follow up; human; liver fibrosis; liver stiffness; longitudinal study; major clinical study; male; priority journal; retrospective study; Taiwan; tertiary care center; chronic hepatitis B; complication; diagnostic imaging; elastography; liver; liver cirrhosis; middle aged; pathology; procedures; very elderly; young adult; Adult; Aged; Aged, 80 and over; Antiviral Agents; Cohort Studies; Elasticity Imaging Techniques; Female; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Retrospective Studies; Young Adultjournal article10.1148/radiol.2018171116295845942-s2.0-85050258383