Chuang K.-J.CHANG-CHUAN CHANTA-CHEN SULee C.-T.Tang C.-S.2020-09-282020-09-2820071073-449Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34547941468&doi=10.1164%2frccm.200611-1627OC&partnerID=40&md5=9a888453f14f507a945072ccf173f91chttps://scholars.lib.ntu.edu.tw/handle/123456789/514870Rationale: The biological mechanisms linking air pollution to cardiovascular events still remain largerly unclear. Objectives: To investigate whether biological mechanisms linking air pollution to cardiovascular events occurred concurrently in human subjects exposed to urban air pollutants. Methods: We recruited a panel of 76 young, healthy students from a university in Taipei. Between April and June of 2004 or 2005, three measurements were made in each participant of high-sensitivity Creactive protein (hs-CRP), 8-hydroxy-2′-deoxyguanosine (8-OHdG), plasminogen activator fibrinogen inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA) in plasma, and heart rate variability (HRV). Gaseous air pollutants were measured at one air-monitoring station inside their campus, and particulate air pollutants were measured at one particulate matter supersite monitoring station 1 km from their campus.Weused linear mixed-effects models to associate biological endpoints with individual air pollutants averaged over 1- to 3-day periods before measurements were performed. Measurements and Main Results: We found that increases in hs-CRP, 8-OHdG, fibrinogen, and PAI-1, and decreases in HRV indices were associated with increases in levels of particles with aerodynamic diameters less than 10 μm and 2.5 μm, sulfate, nitrate, and ozone (O3) in single-pollutant models. The increase in 8-OHdG, fibrinogen, and PAI-1, and the reduction in HRV remained significantly associated with 3-day averaged sulfate and O3 levels in two-pollutant models. There were moderate correlations (r = -0.3) between blood markers of hs-CRP, fibrinogen, PAI-1, and HRV indices. Conclusions: Urban air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction simultaneously in healthy young humans, with sulfate and O3 as two major traffic-related pollutants contributing to such effects.[SDGs]SDG3[SDGs]SDG118 hydroxydeoxyguanosine; C reactive protein; carbon monoxide; fibrinogen; nitrate; nitrogen dioxide; plasminogen activator inhibitor 1; sulfate; sulfur dioxide; tissue plasminogen activator; adult; air monitoring; air pollution; article; autonomic dysfunction; blood clotting; cardiovascular disease; enzyme linked immunosorbent assay; fibrinolysis; heart rate variability; human; human experiment; humidity; inflammation; normal human; oxidative stress; particulate matter; pneumonia; priority journal; statistical analysis; student; Taiwan; traffic; university student; Adolescent; Adult; Air Pollutants; Air Pollution; Biological Markers; Blood Coagulation; C-Reactive Protein; Deoxyguanosine; Environmental Monitoring; Female; Fibrinogen; Heart Rate; Humans; Inflammation; Male; Oxidative Stress; Particle Size; Plasminogen Activator Inhibitor 1; Taiwan; Tissue Plasminogen Activator; Urban Health; Urban Populationjournal article10.1164/rccm.200611-1627OC174634112-s2.0-34547941468