Lai, Min-NanMin-NanLaiKo, Huey-JiunHuey-JiunKoLEAN-TEIK HUANG2018-09-102018-09-102012-04https://www.scopus.com/pages/publications/84859425264?inwardhttp://scholars.lib.ntu.edu.tw/handle/123456789/370845Antrodia cinnamomea (AC) is a popular medicinal fungus used for treating hypertension, hepatotoxicity and tumors. This study aimed to examine the hypolipidemic properties of A. cinnamomea extracts (ACE) in high-fat diet-fed hamsters. Results showed that at concentrations 500, 1,000 and 1,500mg/kg, ACE showed no significant effect on total cholesterol and high-density lipoprotein concentrations, but a trend of decrease in plasma triglycerides and low-density lipoprotein (LDL) levels was noted, and a significant reduction in LDL was observed at 1,500mg/kg ACE. ACE caused a significant decrease in liver triglycerides and total cholesterol concentrations. ACE possessed the ability to enhance superoxide dismutase, catalase and glutathione peroxidase production, and reduced the thiobarbituric acid-reactive substances level in hyperlipidemic hamsters. These results conclude that ACE is able to lower the plasma triglycerides and LDL, liver triglycerides and total cholesterol concentrations, as well as enhancing the level of antioxidant enzymes.[SDGs]SDG3journal article10.1111/j.1745-4514.2010.00530.x2-s2.0-84859425264