2015-08-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/646159摘要：背景：泛自閉光譜症候群(Autism spectrum disorder ，ASD)為一以社會和溝通障礙為主要特徵的神經發展疾病。然而，雖然較少被強調，ASD常伴隨著許多和動作相關的障礙， 例如在模仿、理解或計劃動作上的困難。這些動作相關的能力，為參與「動作認知」的 重要過程；而「動作表徵」為動作認知的一個基本元素。雖然多數研究廣泛地透過動作 模仿和動作觀察來研究動作表徵。然而，關於ASD在動作表徵上是否有缺陷的議題， 仍然不一致且具有爭議。研究目的：在目前正在執行的研究計晝中（MOST 103-2314-B002-030)，我們藉由「動作想像」 來探討ASD動作表徵的特性。透過動作想像，我們得以直接探討動作表徵的内在操作。 我們目前的心理物理學資料顯示（自閉組n=10，控制組n=10)，相較於控制組，ASD有 較無效率、但仍有功能的動作想像能力。本計晝則預計延續此結果作進一步的探討，有 兩個主要的研究目的：一、探討ASD在執行動作想像時的神經生理學機制。二、探討 在動作想像上的改變，是否和ASD在動作計劃和動作控制上的困難有關。研究方法：針對研究目的一，第一年的實驗一會藉由結合腦電波和手部旋轉實驗典範，探討 ASD動作想像的神經機制。針對研究目的二，第二年的實驗二會透過運動學分析，研究 ASD的動作想像能力和其動作計劃、動作控制表現的相關性。預期成果：研究目的一的結果將有助於釐清ASD可能轉變的動作表徵下的神經機制。基於目 前的行為學研究結果，在mu波的抑制上，我們假設ASD會呈現和控制組相似的”生物 力學侷限因素”。然而，由於ASD在運動覺動作想像的較無效率，兩個組別可能會在中 央體感動作相關腦區的mu波，有振幅和發生時間上的差異。研究二的結果則有助於進 一步了解ASD在動作計劃和動作控制上的障礙，是否和動作表徵的改變有相關性。因 此，此研究計劃多面向的結果，將可以幫助我們了解ASD的動作認知能力以及其與動 作相關障礙的關聯性。<br> Abstract: Background:Autism spectrum disorder (ASD) is a neurodevelopmental disorder mainly characterized by social and communication impairments. Although less emphasized, ASD indeed suffers from various motor-related deficits such as imitation, understanding and planning of actions, which are all key processes involved in motor cognition. Most of previous research has extensively studied action representation, a basic component of motor cognition, through action imitation and action observation. However, whether ASD has deficits in action representation remains controversial and inconsistent.Objectives:In our previous proposal (MOST 103-2314-B002-030), we proposed to study the characteristics of action representation in ASD through motor imagery (MI) that allows us to directly investigate the internal embodiment of action representation. Our psychophysics data so far (ASD: n = 10, Typical development (TD): n = 10) reveals that ASD show less efficient, but not impaired, capability of motor imagery than the TD group. In the current proposal, we propose to continue our research line with two specific aims. First, we will further investigate the underlying neurophysiological mechanism of the potentially altered MI in ASD. Second, we will investigate whether alteration of motor imagery is associated with deficiency in motor planning and motor control in ASD.Methods:For Aim 1 (Exp I, 1st year), we will investigate the neural mechanisms of motor imagery in ASD using EEG combined with the hand rotation paradigm developed in the previous psychophysics experiment. For Aim 2 (Exp II, 2nd year), we will explore the relationship between the capability of motor imagery and performance of motor planning and control through kinematic analysis approach in the second year.Anticipated Results:Results from Aim 1 will help reveal the neural mechanism of the possible altered action representation in ASD. Based on our current behavioral results, we hypothesize that the ASD individuals may show the “biomechanical constraint effect” pattern of mu-power attenuation similar to the TD group. However, due to the inefficiency of kinesthetic MI in the ASD group, the two groups may result in power and latency differences in mu rhythm over the central scalp region. Results from Aim 2 will further help reveal whether deficits in motor planning and control correlates with altered action representation in ASD. The overarching results of the current proposal will therefore provide important insights into the capability of motor cognition of ASD and its relationship with their motor related deficits.泛自閉症光譜症候群動作認知動作想像腦電波神經震盪運動學分析Autism Spectrum Disordermotor cognitionmotor imageryEEGneuronal oscillationkinematic analyses