Anbazhagan, R.R.AnbazhaganSu, Y.-A.Y.-A.SuTsai, H.-C.H.-C.TsaiJeng, R.-J.R.-J.JengRU-JONG JENG2018-09-102018-09-102016http://www.scopus.com/inward/record.url?eid=2-s2.0-84955493321&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/397286Despite their frequent usages as contrast agents for in vivo MRI imaging, paramagnetic molecules continue to suffer from low resolution, physicochemical instability, and high toxicity. Herein, we present a molybdenum disulfide and gadolinium complex, as an alternative core-shell magnetic nanomaterial that exhibits enhanced paramagnetic property; 4.5-times longer water proton spin-lattice relaxation time (T1) when compared to commercial gadolinium contrast agents; as well as lowered toxicity, extended blood circulation time, increased stability, and desirable excretion characteristic. Transmission electron microscopy (TEM) revealed smooth core-shell nanoparticles 100 nm in size with a shell width of approximately 10 nm. These findings suggest that the synthesized nanomaterial possesses high potential as a positive contrast agent for the enhancement of MRI imaging. ? 2015 American Chemical Society.contrast agents; core-shell structure; enhanced T1 value; in vivo imaging enhanced excretion; molybdenum disulfide nanoparticle[SDGs]SDG3[SDGs]SDG6Cardiovascular system; Gadolinium; High resolution transmission electron microscopy; Magnetic materials; Magnetic resonance imaging; Magnetism; Molybdenum compounds; Nanoparticles; Nanostructured materials; Paramagnetism; Physiology; Toxicity; Transmission electron microscopy; Contrast agent; Core shell structure; Enhanced excretion; Enhanced T; Molybdenum disulfide; Shells (structures); chelating agent; contrast medium; disulfide; gadolinium; molybdenum; molybdenum disulfide; nanomaterial; animal; chemistry; drug effects; female; human; Institute for Cancer Research mouse; magnetism; nuclear magnetic resonance imaging; particle size; procedures; signal processing; static electricity; thermodynamics; ultrastructure; umbilical vein endothelial cell; X ray photoelectron spectroscopy; Animals; Chelating Agents; Contrast Media; Disulfides; Female; Gadolinium; Human Umbilical Vein Endothelial Cells; Humans; Magnetic Phenomena; Magnetic Resonance Imaging; Mice, Inbred ICR; Molybdenum; Nanostructures; Particle Size; Photoelectron Spectroscopy; Signal Processing, Computer-Assisted; Static Electricity; Thermodynamicsjournal article10.1021/acsami.5b09722