Su W.-J.PEI-LAN SHAOLiu M.-T.DING-PING LIUKUO-CHIN HUANGLUAN-YIN CHANGCHUN-YI LUWang J.-R.Shih S.-R.Huang D.T.-N.Chi H.LI-MIN HUANG2020-12-152020-12-1520101058-4838https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954697540&doi=10.1086%2f653532&partnerID=40&md5=485f8e49ec6508f4bde2138a4aa21893https://scholars.lib.ntu.edu.tw/handle/123456789/525599Background. Our objective was to determine the serological signals that indicated the possible dominant circulating influenza virus subtypes for the coming influenza seasons. Methods. Healthy children 6 months through 5 years of age, adults 18-60 years of age, and elderly adults >60 years of age were recruited to receive seasonal trivalent inactivated influenza vaccinations from October through December during the 2006-2007 and 2008-2009 seasons. Paired serum samples were collected at baseline and at 3 weeks after vaccination. Using a hemagglutination inhibition (HAI) assay, we measured antibody responses to local influenza strains circulating early in October, before each winter influenza season. Results. A total of 301 subjects were tested for antibody to local strains (80, 120, and 101 subjects in the 2006-2007, 2007-2008, and 2008-2009 seasons, respectively). The dominant winter influenza strains in Taiwan were B/Malaysia/2506/2004-like in the 2006-2007 season, A/Brisbane/59/2007-like virus (H1N1) in the 2007-2008 season, and A/Brisbane/59/2007-like virus (H1N1) in the 2008-2009 season. The group with the lowest number of subjects with an HAI titer of ?40 at baseline was children with antibody against the B/Taiwan/0050/2006 in the 2006-2007 season, A/Taiwan/785/2006 (H1N1) in 2007-2008 season, and A/Taiwan/951/2007 (H1N1) in 2008- 2009 season. The emergence of these viruses correlated well with the circulating influenza subtype in the following winter peak seasons. Conclusions. Low seroprotection rate among children against a specific locally circulating influenza strain might predict the dominantly circulating subtype of influenza virus in the coming winter season. A year-end preseasonal serological survey of children could provide valuable information about the possible circulating strain and tailor the disease-control strategy accordingly. ? 2010 by the Infectious Diseases Society of America. All rights reserved.[SDGs]SDG3inactivated virus vaccine; influenza vaccine; influenza vaccine; virus antibody; adolescent; adult; antibody response; antibody titer; article; blood sampling; child; epidemic; hemagglutination inhibition test; human; infant; Influenza virus A H1N1; Influenza virus A H3N2; major clinical study; predictor variable; preschool child; priority journal; school child; seasonal influenza; serology; Taiwan; vaccination; virus strain; winter; aged; blood; classification; immunology; Influenza, Human; isolation and purification; male; middle aged; Orthomyxovirus; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Viral; Child, Preschool; Hemagglutination Inhibition Tests; Humans; Infant; Influenza Vaccines; Influenza, Human; Male; Middle Aged; Orthomyxoviridae; Taiwan; Young Adultjournal article10.1086/653532205284782-s2.0-77954697540