2010-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/688919摘要：本計畫主要在開發生物纖維應用做為創傷敷料的潛力。創傷敷料應具有減少水分蒸發、減輕疼痛、保護傷口、抑制傷口細菌數量及促進傷口癒合等功能，因此本計畫第一年首先針對合作廠商利用微生物發酵所獲得之纖維素類生物纖維進行完整的物化特性分析，瞭解製程參數對其物化特性的影響。隨後進行細胞測試瞭解其對細胞之影響，並進行動物實驗，篩選出具傷口癒合功能性及安全性的生物纖維製程參數。第二年將由製程改進引入具有抗菌性之奈米銀或幾丁聚醣，進行抗菌實驗及動物實驗，創造出具有抗菌加值結果之生物纖維敷料，並建立合適之滅菌方法與確效流程。此二年期產學合作計畫期望提昇此生物纖維成為新穎的臨床外科敷料。<br> Abstract: The proposed project is to investigate the potential biological applications of bio-fibers as wound dressings. The bio-fibers are the natural polymer of bacterial cellulose, which has been used as a cosmetic dressing. In the first year, the physico-chemical properties of the bacterial cellulose under different processing parameters will be characterized and in vitro cell culture as well as in vivo animal experiments will be conducted to select the appropriate processing parameters and confirm the efficacy and safety of the bio-fibers. In the second year, antibacterial components such as nanosilver or chitosan will be introduced in the fabrication process to equip the bio-fibers with antibacterial activities. The adequate sterilization method and validation of sterility will be established. Through this two-year project, we expect to bring the potential bio-fibers into the medical device market as novel dressing materials.生物纖維敷料之開發與應用(2/2)