2023-01-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/653382開發PAG 在肺癌、乳癌和眼睛感染抗藥應用之研究 Drug resistance continues to be one of the biggest challenges in cancer therapy [1]. Generally, the role of biomaterials in preventing drug resistance in cancer research focuses on encapsulating drugs to prepare nanoparticles to gain access to cancer cells [2]. Up to now, few study reported that polymer biomaterial itself provides the potential to bypass drug resistance or the synergistic effect with drugs in cancer therapy. In addition, the problem of drug resistance in cancer is similar to the infectious disease, in that both chemotherapeutic and antimicrobial therapies are quickly tempered due to drug-resistance to lead to disease reversion. Therefore, the purpose of this project aims to develop a novel biomaterial poly (allylguanidine) (PAG) to overcome or prevent the drug resistance in lung and breast cancer chemotherapy, and in ocular infection antimicrobial therapy, and to investigate possible mechanisms for new treatment strategies.抗藥性;生醫材料;聚（N-取代丙烯醯胺）;化療;Drug resistance; biomaterial; poly (allylguanidine) (PAG); chemotherapy