Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse

Kung, YiYiKungKUAN-YU CHENLiao, Wei-HaoWei-HaoLiaoHsu, Yi-HuaYi-HuaHsuCHUEH-HUNG WUMING-YEN HSIAOABEL PO-HAO HUANGWEN-SHIANG CHEN2022-01-262022-01-262022-01-062045-8118https://scholars.lib.ntu.edu.tw/handle/123456789/593654The blood-cerebrospinal fluid (CSF) barrier (BCSFB) is critically important to the pathophysiology of the central nervous system (CNS). However, this barrier prevents the safe transmission of beneficial drugs from the blood to the CSF and thus the spinal cord and brain, limiting their effectiveness in treating a variety of CNS diseases.enBlood-cerebrospinal fluid barrier; Blood–brain barrier; Central nervous system; Glioblastoma multiforme; Leptomeningeal carcinomatosis; Low-energy extracorporeal focused shockwave pulseFacilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulsejournal article10.1186/s12987-021-00303-x349916472-s2.0-85122535052WOS:000739949800001https://api.elsevier.com/content/abstract/scopus_id/85122535052