Huang J.-W.Pan H.-J.Yao W.-Y.Tsao Y.-W.WEI-YU LIAOWu C.-W.Tung Y.-C.Lee C.-H.2020-07-212020-07-2120131473-0197https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875826879&doi=10.1039%2fc2lc41050h&partnerID=40&md5=7bb44fae7a6a50360d2b9cd2c2351008https://scholars.lib.ntu.edu.tw/handle/123456789/510302Using a cell culture chip with a deformable substrate driven by a hydraulic force, we investigated the motility of cancer cells affected by myofibroblasts undergoing cyclic tensile strain (CTS). CTS reduced both the expression of α-smooth muscle actin in the myofibroblast and the ability of the myofibroblast to accelerate cancer cell migration. However, with the treatment of a pro-inflammatory factor interleukin-1β on the myofibroblasts, the effects of CTS on the myofibroblast were diminished. This result suggests an antagonism between mechanical and chemical stimulations on mediating cancer metastasis by the stromal myofibroblast. ? 2013 The Royal Society of Chemistry.[SDGs]SDG3alpha smooth muscle actin; interleukin 1beta; article; cancer cell; cancer cell culture; cell interaction; cell migration; cell motility; controlled study; cyclic tensile strain; force; human; human cell; hydraulic conductivity; lung cancer; mechanical stimulation; metastasis; myofibroblast; priority journal; protein expression; stimulation; stroma cell; tensile strengthjournal article10.1039/c2lc41050h2-s2.0-84875826879