2017-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/670851摘要： "室内空污如二手菸、油煙、焚香等PM2.5微粒，已成為人類慢性阻塞性肺病/氣喘惡化甚 至死亡的重要原因。伴侣動物犬貓可自然罹患慢性氣道疾病，且與人類飼主曝露於相同室内 空污環境，在「One medicine」世界趨勢下，有潛力成為探討室内空污對慢性氣道疾病影響的 自發疾病動物模式。本團隊的初步資料顯示，44%寵物犬貓家中PM2.5濃度超過室内健康容 許範圍(>35 ng/m3)，且罹患呼吸疾病的動物家中PM2.5濃度有較高趨勢；此外98%飼主同意 接受長期追蹤，有利於預計進行的前瞻性追蹤研究。 本延續性計劃選定獸醫與人類醫學共同關注的慢性氣道疾病如慢性支氣管炎與氣喘，收 集犬貓病患下呼吸道檢體與臨床數據，以橫斷式病例對照法評估室内PM2.5濃度高低與疾病 嚴重度之關係；前計劃中同意長期追蹤之個案，採前瞻性病例對照追蹤法探討曝露於室内空 污物一段時間後肺功能變化與導致慢性症狀惡化之因果關係。 計劃結果預計呈現伴侣動物自然罹患之慢性氣道疾病受室内空污的影響與人類相似，曝 露於較高室内PM2.5濃度者其疾病嚴重度增加，原先無症狀者則逐漸發展出慢性氣道疾病。 在此模式下未來可進行世代長期追蹤、評估室内空污防治策略效益、規劃治療空污相關呼吸 疾病之臨床試驗；空污對家庭寵物的健康危害也有助於空污防治之宣導。" Abstract: "Household air pollution (HAP) (eg, PM2.5 from second hand smoke, cooking or burning incense) has been associated with an increased risk of exacerbation of chronic obstructive pulmonary disease/asthma or death in humans. The clinical findings of naturally occurring chronic airway disease in pet dogs/cats are very similar to what are seen in humans; therefore, these companion animals sharing the same indoor air quality with their human owners may be of great potential to be used as a spontaneous disease model for HAP-related airway disease. In view of the worldwide trend of 'one medicine，，the impact of HAP on respiratory health care shall be a prominent issue on both human and veterinary medicine. The preliminary results of our previously approved project (MOST 105-2313-B-002-055 work in progress) showed that 44% of pet households were found to have elevated PM2.5 concentration (> 35 |ig/m3). The concentration of PM2.5 is higher in the households that owing pets present with respiratory signs than in the households that owning pets without respiratory signs. Moreover, 98% of pet owners signed for the agreement for enrollment in a more long-term follow-up plan, being beneficial to the subsequent longitudinal prospective study. This continued project will be focused on chronic airway disease (chronic bronchitis/asthma), which is the common interest of both medical and veterinary professions. To evaluate the association between PM2.5 exposure and clinical severity of chronic airway disease in pet dogs/cats a cross-section, case-control study on canine/feline patients with chronic airway disease will be conducted during 20 months. All cases will be categorized into high or low PM2.5 exposure group according to indoor 24h PM2.5 concentration in the household. Detailed clinical data and lower airway samples will be collected in each case. PM2.5 level will be analyzed with inflammation extent of lower airway, pulmonary function change, and clinical severity score. The second aim of this continued project is to assess medium-term adverse impact of HAP on respiratory health through a prospective, case-control longitudinal observational study. With the pet owners’ agreement for future follow-up in our preceded project (MOST 105-2313-B-002-055 -), pet dogs/cats with baseline data will be reassessed in 2 years. The changes on clinical signs and pulmonary function between groups with presence or absence of HAP will be compared. We expect to see the impact of exposure to HAP in companion animals with naturally-acquired chronic airway disease is similar to humans - Increased level in household PM2.5 is significantly associated with more advanced disease severity, and the presence of HAP can gradually induce chronic airway disease in previously healthy animals. Through this project, future cohort studies with a more long-term follow-up period for prognosis, assessment for the efficacy of HAP control strategy, and clinical trials of therapeutics on HAP-related airway disease can be organized under this spontaneous disease model. Furthermore, family pets have become important members in many families, which can increase public attention on HAP control when it is also a health threat to their pets."室内空污PM2.5慢性阻塞性肺病氣喘慢性支氣管炎慢性氣道疾病伴估動物犬雜肺功能自發疾病動物模式Household air pollutionChronic obstructive pulmonary diseaseAsthmaChronic airway diseaseCompanion animalsDogsCatsPulmonary functionSpontaneous disease model