Ranade K.Hinds D.Hsiung C.A.LEE-MING CHUANGChang M.-S.Chen Y.-T.Pesich R.Hebert J.Chen Y.-D.I.Dzau V.Olshen R.Curb D.Botstein D.Cox D.R.Risch N.2020-06-012020-06-0120030895-7061https://www.scopus.com/inward/record.uri?eid=2-s2.0-12244276719&doi=10.1016%2fS0895-7061%2802%2903245-4&partnerID=40&md5=f9ed6d264e3900a014aa0baaf5e7d3ddhttps://scholars.lib.ntu.edu.tw/handle/123456789/495512Background: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at ?10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population. ? 2003 American Journal of Hypertension, Ltd.[SDGs]SDG3adult; article; Chinese; chromosome 10p; controlled study; female; gene frequency; gene locus; genetic susceptibility; genotype; human; hypertension; Japan; major clinical study; male; priority journal; Adult; Asian Continental Ancestry Group; China; Chromosome Mapping; Chromosomes, Human, Pair 10; Genetic Predisposition to Disease; Genome, Human; Humans; Hypertension; Japan; Lod Score; Middle Agedjournal article10.1016/S0895-7061(02)03245-4125596862-s2.0-12244276719