Tsai, Ya-ChuYa-ChuTsaiTSEN-FANG TSAI2022-09-202022-09-202022-05-1516616596https://scholars.lib.ntu.edu.tw/handle/123456789/621244Psoriasis (PSO) and atopic dermatitis (AD) were once considered to be mutually exclusive diseases, but gradually regarded as a spectrum of disease. Shared genetic loci of both diseases were noted in some populations, including Chinese. Shared immunopathogenesis involving Th17, Th1, Th22 cells, or even IL-13 was found in certain stages or phenotypes. This review discusses the overlapping genetic susceptibility, shared cytokines, immune-mediated comorbidities, and clinical presentations. Overlapping conditions could be classified into mainly PSO lesions with AD features or vice versa, concomitant PSO and AD, or disease transformation as a result of biologics treatment.enatopic dermatitis; concomitant; overlap; paradoxical; psoriasis; psoriasis dermatitis[SDGs]SDG3review10.3390/ijms23105518356283272-s2.0-85130154689WOS:000802689500001https://api.elsevier.com/content/abstract/scopus_id/85130154689