Chang Y.-S.BOR-LUEN CHIANG2021-07-022021-07-0220180091-6749https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053841953&doi=10.1016%2fj.jaci.2018.08.005&partnerID=40&md5=16fc3eb03858fed329c94fa57a08c58ehttps://scholars.lib.ntu.edu.tw/handle/123456789/567747Sleep disturbance is very common in patients with atopic dermatitis (AD) and is a major factor leading to impaired quality of life. Sleep disturbance is often viewed as one of the symptoms of AD and one of the measures of disease severity. In this review we describe a variety of sleep disorders associated with AD and a wide range of effect that sleep disorders have on patients with AD. We also discuss our current understanding of the mechanism of sleep disturbance in patients with AD. The relationship between sleep disorders and AD might be bidirectional and could form a vicious cycle. Therefore we suggest viewing sleep disorders as a comorbidity of AD for which regular screening and bidirectional management strategies are indicated, with equal focus on maintaining disease control and implementing specific strategies to improve sleep. ? 2018atopic dermatitis; eczema; melatonin; sleep disorder; Sleep disturbance[SDGs]SDG3Article; atopic dermatitis; comorbidity; disease exacerbation; human; insomnia; pathogenesis; patient care; priority journal; pruritus; quality of life; sleep disorder; sleep disordered breathing; animal; atopic dermatitis; comorbidity; sleep disorder; Animals; Comorbidity; Dermatitis, Atopic; Humans; Sleep Wake Disordersjournal article10.1016/j.jaci.2018.08.005301444722-s2.0-85053841953