JIAN-TE LEEHUNG-CHIEH CHOUPO-NIEN TSAOWU-SHIUN HSIEHWUH-LIANG HWU2020-12-162020-12-1620040929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-3342902781&partnerID=40&md5=4888885708e0ddf5258ec165f2340a1ahttps://scholars.lib.ntu.edu.tw/handle/123456789/526034The incidence of trisomy 18 in monozygotic twins is approximately 1 per million. We report a pair of liveborn monozygotic twins with trisomy 18. Both twins had esophageal atresia with tracheoesophageal fistula (Type C) and intrauterine growth retardation. Twin A had cleft lip, choanal atresia and perimembranous ventricular septal defect. Twin B had Hypoplastic left heart syndrome. The twins died without aggressive intervention at the age of 2 months and 52 hours, respectively. These 2 babies had significantly discordant phenotypes, which suggests an epigenetic or environmental effect. Bioethical considerations remain important in the care of babies with multiple congenital anomalies.[SDGs]SDG3article; case report; cesarean section; choana atresia; chromosome analysis; cleft lip; death; environmental factor; epigenetics; esophagus atresia; female; heart ventricle septum defect; human; hypoplastic left heart syndrome; incidence; infant; intrauterine growth retardation; medical ethics; monozygotic twins; newborn care; phenotype; tracheoesophageal fistula; trisomy 18; twin discordance; chromosome 18; genetics; monozygotic twins; multiple malformation syndrome; newborn; trisomy; twins; Abnormalities, Multiple; Chromosomes, Human, Pair 18; Diseases in Twins; Female; Humans; Infant, Newborn; Phenotype; Trisomy; Twins, Monozygoticjournal article151758302-s2.0-3342902781