WAN-YU CHENFang, Ku HaoKu HaoFangCHUN-WEI WANGLiao, Chun TaChun TaLiaoYen, Tzu ChenTzu ChenYenFang, Taun JenTaun JenFangSHIH-FAN LAIHSIANG-KUANG LIANG2021-12-172021-12-172021-12-012378-8038https://scholars.lib.ntu.edu.tw/handle/123456789/590113Objective: Whether to administer adjuvant treatment is a matter of great debate for oral cavity cancer harboring a single positive node without extranodal extension and positive margin (defined as low/intermediate risk pN1new in this study). Methods: A total of 243 low/intermediate risk pN1new patients with oral cavity cancer who received curative surgery were included. Overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant metastasis-free survival (DMFS) were compared between patients receiving adjuvant treatment and observation alone. Results: For patients receiving adjuvant therapy vs observation, the differences in outcomes were not statistically significant in terms of 5-year OS, LRFS, RRFS, and DMFS. For subgroup analysis, in low/intermediate pN1new patients with one or more minor risk factors, adjuvant therapy was not significantly associated with OS, LRFS, RRFS, or DMFS in pN1new patients. Conclusion: For low/intermediate risk pN1new patients with oral cavity cancer, adjuvant therapy might be omitted. Level of Evidence: 4.adjuvant radiotherapy | oral cancer | risk factor | single node | surgeryadjuvant radiotherapy; oral cancer; risk factor; single node; surgery[SDGs]SDG3cisplatin; adjuvant radiotherapy; adult; aged; Article; bone scintiscanning; cancer adjuvant therapy; cancer prognosis; cancer staging; cancer surgery; chemoradiotherapy; computer assisted tomography; distant metastasis free survival; female; human; intensity modulated radiation therapy; intermediate risk patient; local recurrence free survival; low risk patient; lymph node; lymph vessel metastasis; major clinical study; male; mouth cancer; multicenter study (topic); neck dissection; nuclear magnetic resonance imaging; overall survival; perineural invasion; positron emission tomography; proton therapy; radiation dose; recurrence free survival; regional recurrence free survival; retrospective study; risk assessment; risk factor; thorax radiography; volumetric modulated arc therapyjournal article10.1002/lio2.6792-s2.0-85117168793https://scholars.lib.ntu.edu.tw/handle/123456789/587476