CHO, SHENG LISHENG LICHOWEN-CHIEN CHOU2022-09-052022-09-052021-06-0110167390https://scholars.lib.ntu.edu.tw/handle/123456789/617776Histiocytoid Sweet's syndrome is a recently described histopathologic variant of Sweet's syndrome. This is the first case report describing histiocytoid variant of Sweet's syndrome caused by all-trans retinole acid in a patient with acute promyelocytic leukemia. We present a 30-year-old man with newly diagnosed acute promyelocytic leukemia who received induction chemotherapy containing all-trans retinole acid and developed fever and painful erythematous cutaneous papules on day 13 of therapy. A diagnosis of histiocytoid Sweet's syndrome was made. All-trans retinoic acid was considered the culprit drug to induce this event. Treatment with corticosteroids Improved the systemic and cutaneous signs. A literature search identified only 17 eases of Sweet's syndrome during all-trans retinoic acid therapy, but none were of the histiocytoid variant. The presented clinical course resembles previously reported cases of Sweet's syndrome. This case emphasizes the rare effect of all-trans retinoic acid therapy causing histiocytoid Sweet's syndrome manifesting as fever and skin papules.Acute promyelocytic leukemia | Case report | Drug-related side effects | Retinoic acid | Sweet's syndrome[SDGs]SDG3journal article10.6314/JIMT.202106_32(3).072-s2.0-85129314797https://scholars.lib.ntu.edu.tw/handle/123456789/610985