Shi, JianxinJianxinShiShiraishi, KouyaKouyaShiraishiChoi, JiyeonJiyeonChoiMatsuo, KeitaroKeitaroMatsuoChen, Tzu-YuTzu-YuChenDai, JunchengJunchengDaiHung, Rayjean JRayjean JHungChen, KexinKexinChenShu, Xiao-OuXiao-OuShuKim, Young TaeYoung TaeKimLandi, Maria TeresaMaria TeresaLandiChen, Kun-ChiehKun-ChiehChenGao, Yu-TangYu-TangGaoQian, BiyunBiyunQianWu, ChenChenWuLu, DaruDaruLuLiu, JianjunJianjunLiuSchwartz, Ann GAnn GSchwartzHoulston, RichardRichardHoulstonSpitz, Margaret RMargaret RSpitzGorlov, Ivan PIvan PGorlovLin, DongxinDongxinLinWu, XifengXifengWuYang, PingPingYangLam, StephenStephenLamTardon, AdoninaAdoninaTardonChen, ChuChuChenBojesen, Stig EStig EBojesenJohansson, MattiasMattiasJohanssonRisch, AngelaAngelaRischBickeböller, HeikeHeikeBickeböllerJi, Bu-TianBu-TianJiZheng, WeiWeiZhengWichmann, H-ErichH-ErichWichmannChristiani, David CDavid CChristianiRennert, GadiGadiRennertArnold, SusanneSusanneArnoldBrennan, PaulPaulBrennanMcKay, JamesJamesMcKayField, John KJohn KFieldShete, Sanjay SSanjay SSheteLe Marchand, LoicLoicLe MarchandLiu, GeoffreyGeoffreyLiuYin, ZhihuaZhihuaYinAndrew, AngelineAngelineAndrewKiemeney, Lambertus ALambertus AKiemeneyZienolddiny-Narui, ShanShanZienolddiny-NaruiGrankvist, KjellKjellGrankvistJohansson, MikaelMikaelJohanssonCox, AngelaAngelaCoxTaylor, FionaFionaTaylorYuan, Jian-MinJian-MinYuanLazarus, PhilipPhilipLazarusSchabath, Matthew BMatthew BSchabathZhou, BaosenBaosenZhouAldrich, Melinda CMelinda CAldrichJeon, Hyo-SungHyo-SungJeonJiang, Shih ShengShih ShengJiangSung, Jae SookJae SookSungChen, Chung-HsingChung-HsingChenHsiao, Chin-FuChin-FuHsiaoJung, Yoo JinYoo JinJungGuo, HuanHuanGuoHu, ZhibinZhibinHuBurdett, LaurieLaurieBurdettSong, BaoBaoSongYeager, MeredithMeredithYeagerHutchinson, AmyAmyHutchinsonHicks, BelyndaBelyndaHicksLiu, JiaJiaLiuZhu, BinBinZhuBerndt, Sonja ISonja IBerndtWu, WeiWeiWuWang, JunwenJunwenWangLi, YuqingYuqingLiChoi, Jin EunJin EunChoiWang, JiucunJiucunWangPark, Kyong HwaKyong HwaParkSung, Sook WhanSook WhanSungLiu, LiLiLiuKang, Chang HyunChang HyunKangWang, Wen-ChangWen-ChangWangXu, JunJunXuGuan, PengPengGuanTan, WenWenTanCHONG-JEN YUYang, GongGongYangSeow, Wei JieWei JieSeowSihoe, Alan Dart LoonAlan Dart LoonSihoeChen, YingYingChenChoi, Yi YoungYi YoungChoiKim, Jun SukJun SukKimYoon, Ho-IlHo-IlYoonPark, In KyuIn KyuParkXu, PingPingXuHe, QinchengQinchengHeWang, Chih-LiangChih-LiangWangHung, Hsiao-HanHsiao-HanHungSong, LeiLeiSongVermeulen, Roel C HRoel C HVermeulenCheng, IonaIonaChengWu, JunjieJunjieWuLim, Wei-YenWei-YenLimTsai, Fang-YuFang-YuTsaiChan, John K CJohn K CChanLi, JihuaJihuaLiChen, HongyanHongyanChenLin, Hsien-ChihHsien-ChihLinJin, LiLiJinChang, I-ShouI-ShouChangLiu, JieJieLiuSawada, NorieNorieSawadaYamaji, TaikiTaikiYamajiWyatt, KathleenKathleenWyattLi, Shengchao AShengchao ALiMa, HongxiaHongxiaMaZhu, MengMengZhuWang, ZhehaiZhehaiWangCheng, SensenSensenChengLi, XuelianXuelianLiHu, WeiWeiHuRen, YangwuYangwuRenChao, AnnAnnChaoIwasaki, MotokiMotokiIwasakiZhu, JunjieJunjieZhuJiang, GeningGeningJiangFei, KeKeFeiWu, GuopingGuopingWuChen Chih-YiChen, Chien-JenChien-JenChenPAN-CHYR YANGChien, Li-HsinLi-HsinChienYu, JinmingJinmingYuStevens, Victoria LVictoria LStevensFraumeni, Joseph FJoseph FFraumeniChatterjee, NilanjanNilanjanChatterjeeGorlova, Olga YOlga YGorlovaHsiung, Chao AgnesChao AgnesHsiungAmos, Christopher IChristopher IAmosShen, HongbingHongbingShenChanock, Stephen JStephen JChanockRothman, NathanielNathanielRothmanCai, QiuyinQiuyinCaiKohno, TakashiTakashiKohnoLan, QingQingLanHong, Yun-ChulYun-ChulHongKim, Hee NamHee NamKimWu, Yi-LongYi-LongWuWong, Maria PikMaria PikWongRichardson, Brian DouglasBrian DouglasRichardsonFunderburk, Karen MKaren MFunderburkLi, ShilanShilanLiZhang, TongwuTongwuZhangBreeze, CharlesCharlesBreezeWang, ZhaomingZhaomingWangBlechter, BatelBatelBlechterBassig, Bryan ABryan ABassigKim, Jin HeeJin HeeKimAlbanes, DemetriusDemetriusAlbanesWong, Jason Y YJason Y YWongShin, Min-HoMin-HoShinChung, Lap PingLap PingChungYang, YangYangYangAn, She-JuanShe-JuanAnZheng, HongHongZhengYatabe, YasushiYasushiYatabeZhang, Xu-ChaoXu-ChaoZhangKim, Young-ChulYoung-ChulKimCaporaso, Neil ENeil ECaporasoChang, JiangJiangChangHo, James Chung ManJames Chung ManHoKubo, MichiakiMichiakiKuboDaigo, YataroYataroDaigoSong, MinsunMinsunSongMomozawa, YukihideYukihideMomozawaKamatani, YoichiroYoichiroKamataniKobayashi, MasashiMasashiKobayashiOkubo, KenichiKenichiOkuboHonda, TakayukiTakayukiHondaHosgood, Dean HDean HHosgoodKunitoh, HideoHideoKunitohPatel, HarshHarshPatelWatanabe, Shun-IchiShun-IchiWatanabeMiyagi, YoheiYoheiMiyagiNakayama, HaruhikoHaruhikoNakayamaMatsumoto, ShingoShingoMatsumotoHorinouchi, HidehitoHidehitoHorinouchiTsuboi, MasahiroMasahiroTsuboiHamamoto, RyujiRyujiHamamotoGoto, KoichiKoichiGotoOhe, YuichiroYuichiroOheTakahashi, AtsushiAtsushiTakahashiGoto, AkiteruAkiteruGotoMinamiya, YoshihiroYoshihiroMinamiyaHara, MegumiMegumiHaraNishida, YuichiroYuichiroNishidaTakeuchi, KenjiKenjiTakeuchiWakai, KenjiKenjiWakaiMatsuda, KoichiKoichiMatsudaMurakami, YoshinoriYoshinoriMurakamiShimizu, KimihiroKimihiroShimizuSuzuki, HiroyukiHiroyukiSuzukiSaito, MotonobuMotonobuSaitoOhtaki, YoichiYoichiOhtakiTanaka, KazumiKazumiTanakaWu, TangchunTangchunWuWei, FushengFushengWeiDai, HongjiHongjiDaiMachiela, Mitchell JMitchell JMachielaSu, JianJianSuKim, Yeul HongYeul HongKimOh, In-JaeIn-JaeOhLee, Victor Ho FunVictor Ho FunLeeChang, Gee-ChenGee-ChenChangTsai, Ying-HuangYing-HuangTsaiKUAN-YU CHENHuang, Ming-ShyanMing-ShyanHuangSu, Wu-ChouWu-ChouSuChen, Yuh-MinYuh-MinChenSeow, AdelineAdelineSeowPark, Jae YongJae YongParkKweon, Sun-SeogSun-SeogKweon2023-09-042023-09-042023-05-262041-1723https://scholars.lib.ntu.edu.tw/handle/123456789/634961Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.enjournal article10.1038/s41467-023-38196-z372369692-s2.0-85160220141https://api.elsevier.com/content/abstract/scopus_id/85160220141