Tai C.-M.CHUN-JEN LIUMING YAO2021-01-052021-01-0520050929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-24944491770&partnerID=40&md5=e0527e18f75e802d2d203874bedc12d5https://scholars.lib.ntu.edu.tw/handle/123456789/538017Virus-associated hemophagocytic syndrome (VAHS) is a rare complication in acute hepatitis A virus (HAV) infection. There is no standard therapy for VAHS and the clinical course is variable. Data on the use of intravenous immunoglobulin (IVIG) in the treatment of HAV-associated VAHS is limited. We report a previously healthy, 32-year-old man who presented with general malaise, fever, chills and splenomegaly. Laboratory examination showed marked elevation of aminotransferase, leukopenia and thrombocytopenia. Acute hepatitis A was documented by the presence of immunoglobulin M anti-HAV and compatible liver biopsy findings. Bone marrow examination revealed extensive hemophagocytosis, IVIG was administered after the diagnosis of HAV-associated VAHS. His symptoms and laboratory abnormalities improved, and following a smooth recovery he was discharged 1 month after admission.[SDGs]SDG3aminotransferase; hepatitis A antibody; immunoglobulin M; immunoglobulin; acute hepatitis; adult; aminotransferase blood level; article; bone marrow examination; case report; chill; clinical feature; convalescence; disease association; erythrophagocytosis; fever; hemophagocytic syndrome; hepatitis A; human; human tissue; laboratory test; leukopenia; liver biopsy; malaise; male; splenomegaly; thrombocytopenia; treatment outcome; acute disease; hepatitis A; histiocytosis; Acute Disease; Adult; Hepatitis A; Histiocytosis, Non-Langerhans-Cell; Humans; Immunoglobulins, Intravenous; Malejournal article160918282-s2.0-24944491770