Wan, Wei-LinWei-LinWanLin, Yu-JungYu-JungLinShih, Po-ChienPo-ChienShihBow, Yu-RuYu-RuBowCui, QinghuaQinghuaCuiChang, YenYenChangWEI-TSO CHIASung, Hsing-WenHsing-WenSung2024-11-012024-11-012018-07-26https://scholars.lib.ntu.edu.tw/handle/123456789/722670Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H ) is known to have anti-inflammatory effects; however, the bioavailability of directly administered H gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H at inflamed tissues is proposed. The delivery system comprises poly(lactic-co-glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra-muscularly injected close to the OA knee in a mouse model can act as an in situ depot that can evolve gaseous H continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold. The analytical data that are obtained in the biochemical and histological studies indicate that the proposed Mg@PLGA MPs can effectively mitigate tissue inflammation and prevent cartilage from destruction, arresting the progression of OA changes.enhydrogen gasmagnesiummedical gasosteoarthritistissue inflammationjournal article10.1002/anie.20180615929923670