2010-01-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/678880摘要：世界衛生組織的研究報告指出，憂鬱症已於2004年成為世界排名第三之高負擔疾病，並預估將於2030年站上世界排名第一的位子；而焦慮症更是台灣罹病率最高的精神疾病；高齡化的社會，更帶來的大量的阿茲海默症等失智失能人口。精神狀態或認知功能的不健康，不但會造成患者的失能，更影響其家庭與整個社會，增加國家醫療及社會負擔成本；此外，亦會引起死亡。因此，本所擬於本年度進行保健食品紓解精神壓力的研究，期望結合本所各教師的專業領域，進行整合性的研究，自食療、營養、生化的角度，針對具有改善精神與認知功能的保健食品進行有系統、深入、且實用的研究與開發，例如憂鬱症、焦慮症、睡眠障礙、阿茲海默症等，並以營養蛋白質體、營養基因體學，更深入的了解並確定保健食品在神經科學上的影響，未來，更能以人體試驗了解此類保健食品的功效，並將之產品化上市。本年度計畫內容，不但期望在抗憂鬱的學術領域有更傑出的表現，更能將研究成果應用於日常生活中，強化台灣健康產業，改善人類心理健康；並藉此培育我國抗憂鬱之研究人才。 .<br> Abstract: According to WHO report, depression has already been the third high burden disease, and will be the worldwide No. 1 high burden disease by the year 2030. Anxiety is the highest prevalence mental disorder in Taiwan. And the population with dementia is getting larger in the aging society. Unwell mental or cognitive function will bring disability which affect not patients themselves but also the whole society, such as the medical and social burden. Mortality rate is also increased by these illnesses. Therefore, the aim of the project this year is to investigate the functional foods with mental or cognitive improvement effects. From the perspective of diet therapy, nutrition, and biochemistry, a systematic, in-depth and practical research and development in the functional foods with mental or cognitive improvement effects, such as depression, anxiety, sleep disorder, and Alzheimer’s disease, will be done. Proteomics and genomics will be used for mechanism studies in the effects of functional foods on neuroscience. And clinical studies have to be done before the products are available in the market. Hopefully, this project will bring better academic performance in anti-depression, develop more products for prevention of depression, strengthen Taiwan`s health industries, improve human mental health, and train people for anti-depression research.憂鬱症焦慮症營養蛋白質體營養基因體學保健食品depressionanxietyproteomicsgenomicsfunctional foods