Tsai M.-C.Kao L.-T.Lin H.-C.Chung S.-D.Lee, Cha-ZeCha-ZeLee2021-02-022021-02-0220152045-2322https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949522121&doi=10.1038%2fsrep18044&partnerID=40&md5=2b9c505ff36678e76603d1cb697bf540https://scholars.lib.ntu.edu.tw/handle/123456789/545830Despite some studies having indicated a possible association between appendicitis and duodenal ulcers, this association was mainly based on regional samples or limited clinician experiences, and as such, did not permit unequivocal conclusions. In this case-control study, we examined the association of acute appendicitis with peptic ulcers using a population-based database. We included 3574 patients with acute appendicitis as cases and 3574 sex- and age-matched controls. A Chi-squared test showed that there was a significant difference in the prevalences of prior peptic ulcers between cases and controls (21.7% vs. 16.8%, p < 0.001). The adjusted odds ratio (OR) of prior peptic ulcers for cases was 1.40 (95% confidence interval [CI]: 1.24?1.54, p < 0.001) compared to controls. The results further revealed that younger groups demonstrated higher ORs for prior peptic ulcers among cases than controls. In particular, the adjusted OR for cases < 30 years old was as high as 1.65 (95% CI = 1.25?2.19; p < 0.001) compared to controls. However, we failed to observe an association of acute appendicitis with peptic ulcers in the ?60-year age group (OR = 1.19, 95% CI = 0.93?1.52). We concluded that there is an association between acute appendicitis and a previous diagnosis of peptic ulcers.[SDGs]SDG3acute disease; adult; appendicitis; case control study; complication; female; health survey; human; male; middle aged; odds ratio; peptic ulcer; prevalence; register; Taiwan; young adult; Acute Disease; Adult; Appendicitis; Case-Control Studies; Female; Humans; Male; Middle Aged; Odds Ratio; Peptic Ulcer; Population Surveillance; Prevalence; Registries; Taiwan; Young Adultjournal article10.1038/srep18044266434052-s2.0-84949522121