A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer

Ye, Pei-ChenPei-ChenYeLeu, Wohn-JennWohn-JennLeuYeh, Tsung-YuTsung-YuYehHsu, Yu-TungYu-TungHsuLin, Yi-ChinYi-ChinLinWei, Zi-YuanZi-YuanWeiChen, Yi-ChinYi-ChinChenChiang, Yi-ChangYi-ChangChiangHsu, Jui-LingJui-LingHsuChan, She-HungShe-HungChanLIH-CHING HSUJI-WANG CHERNCHAO-WU YUJIH-HWA GUH2024-03-192024-03-192024-02-2002704137https://scholars.lib.ntu.edu.tw/handle/123456789/641117Metastatic castration-resistant prostate cancer (CRPC), the most refractory prostate cancer, inevitably progresses and becomes unresponsive to hormone therapy, revealing a pressing unmet need for this disease. Novel agents targeting HDAC6 and microtubule dynamics can be a potential anti-CRPC strategy.enDNA damage repair; HDAC6 inhibitors; castration-resistant prostate cancer; cisplatin; spindle assembly checkpoint[SDGs]SDG3A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancerjournal article10.1002/pros.24678383755942-s2.0-85185296842https://api.elsevier.com/content/abstract/scopus_id/85185296842