TSU-YAO CHENGMING-SHIANG WUKUO-TAI HUAKuo M.-L.MING-TSAN LIN2020-03-232020-03-2320141007-9327https://www.scopus.com/inward/record.uri?eid=2-s2.0-84894229065&doi=10.3748%2fwjg.v20.i7.1694&partnerID=40&md5=5297e80727de769b0c27037bc4674230https://scholars.lib.ntu.edu.tw/handle/123456789/477430Gastric cancer (GC) is the second leading cause of cancer- related death. The poor survival rate may reflect the relatively aggressive tumor biology of GC. Recently, the importance of the tumor microenvironment in carcinogenesis has emerged. In the tumor microenvironment, tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins capable of modulating carcinogenesis and regulating metastasis. The Cyr61/CTGF/Nov (CCN) proteins are a family of matricellular proteins with variable roles in many physiological and pathological processes. The evidence suggests that CCN family proteins contribute to GC carcinogenic processes. Here, we briefly review recent research on the effects of CCN family proteins in GC carcinogenesis and the development of new targeted agents in this field. ? 2014 Baishideng Publishing Group Co., Limited. All rights reserved.[SDGs]SDG3antisense oligonucleotide; connective tissue growth factor; cyclooxygenase 2; cysteine rich protein 61; epidermal growth factor receptor; hypoxia inducible factor; immunoglobulin enhancer binding protein; mammalian target of rapamycin; monoclonal antibody; nephroblastoma overexpressed protein; phosphatidylinositol 3 kinase; plasminogen activator inhibitor 1; platelet derived growth factor; somatomedin binding protein; transcription factor AP 1; tumor necrosis factor alpha; vasculotropin; vasculotropin A; vasculotropin C; Wnt1 protein; CCN protein; connective tissue growth factor; CTGF protein, human; cysteine rich protein 61; monoclonal antibody; nephroblastoma overexpressed protein; NOV protein, human; signal peptide; article; cancer growth; cancer prognosis; carcinogenesis; human; metastasis; protein expression; signal transduction; stomach carcinoma; survival rate; tumor associated leukocyte; tumor growth; tumor microenvironment; carcinogenesis; chemistry; gene expression regulation; metabolism; mortality; protein tertiary structure; RNA interference; stomach tumor; Antibodies, Monoclonal; Carcinogenesis; CCN Intercellular Signaling Proteins; Connective Tissue Growth Factor; Cysteine-Rich Protein 61; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Nephroblastoma Overexpressed Protein; Protein Sorting Signals; Protein Structure, Tertiary; RNA Interference; Signal Transduction; Stomach Neoplasmsjournal article10.3748/wjg.v20.i7.1694245876482-s2.0-84894229065