SHI-CHUEN MIAWChoi, AndrewAndrewChoiYu, ElaineElaineYuKishikawa, HirokoHirokoKishikawaHo, I. ChengI. ChengHo2019-08-062019-08-062000-01-0110747613https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033696204&doi=10.1016%2fS1074-7613%2800%2980185-5&partnerID=40&md5=d1eca14e1abde9ead8ea28d2972b243ehttps://scholars.lib.ntu.edu.tw/handle/123456789/416256GATA-3 is a T cell-specific transcription factor and is essential for the development of the T cell lineage. Recently, it was shown that the expression of GATA-3 is further induced in CD4+ helper T cells upon differentiation into type 2 but not type 1 effector cells. Here, we report the molecular cloning of a GATA-3 interacting protein, repressor of GATA (ROG). ROG is a lymphoid-specific gene and is rapidly induced in Th cells upon stimulation with anti-CD3. In in vitro assays, ROG represses the GATA-3-induced transactivation. Furthermore, overexpression of ROG in Th clones inhibits the production of Th cytokines. Taken together, our results suggest that ROG might play a critical role in regulating the differentiation and activation of Th cells.enjournal article10.1016/S1074-7613(00)80185-5107556192-s2.0-0033696204https://api.elsevier.com/content/abstract/scopus_id/0033696204