Hsu, Angela Yu-HueyAngela Yu-HueyHsuSUNG-TSANG HSIEH2022-09-082022-09-0820221662-5102https://scholars.lib.ntu.edu.tw/handle/123456789/619159Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood. Our study showed the expression of Dectin-1 on the membrane of macrophages. We also used a sciatic nerve crushing injury model to demonstrate that there was a delay in nerve degeneration-related processes such as breakdown of injured myelinated nerve fibers and formation of myelin ovoid in groups injected with whole glucan particle soluble (WGPS), a Dectin-1 antagonist. There were also fewer intraneural blood vessels in the Dectin-1 antagonist treated group. Our study suggested inhibiting Dectin-1 delayed debris clearance, nerve degeneration, and angiogenesis after peripheral nerve injury.enDectin-1; Wallerian degeneration; macrophage; peripheral nerve injury; peripheral nerve regeneration[SDGs]SDG3journal article10.3389/fncel.2022.810647359662052-s2.0-85135820320WOS:000844453300001https://api.elsevier.com/content/abstract/scopus_id/85135820320