Liang, Chih-KuangChih-KuangLiangLee, Wei-JuWei-JuLeePeng, Li-NingLi-NingPengMeng, Lin-ChiehLin-ChiehMengFEI-YUAN HSIAOChen, Liang-KungLiang-KungChen2024-04-022024-04-022022-0807490690https://scholars.lib.ntu.edu.tw/handle/123456789/641724The coronavirus disease 2019 (COVID-19) pandemic has had strong adverse impacts on vulnerable populations, such as frail older adults. The success of COVID-19 vaccine development, together with extensive global public health efforts, has brought hope to the control of the COVID-19 pandemic. Nevertheless, challenges in COVID-19 vaccine development and vaccination strategies among older people remain. This article reviews vaccinations in older adults, compares COVID-19 vaccine platforms, the efficacy and safety of COVID-19 vaccines in frail older people in long-term care settings, and the challenges of COVID-19 vaccine development and policy making for vaccination strategies in older adults.enCOVID-19; Disability; Frailty; Immunosenescence; Vaccine[SDGs]SDG3review10.1016/j.cger.2022.03.006358686762-s2.0-85132758796https://api.elsevier.com/content/abstract/scopus_id/85132758796