Kang K.-T.PEI-LIN LEEWEN-CHIN WENGWEI-CHUNG HSU2020-07-202020-07-2020120307-0565https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863726148&doi=10.1038%2fijo.2012.5&partnerID=40&md5=362db0e0da80f5f8c7ac6c163db53a6ahttps://scholars.lib.ntu.edu.tw/handle/123456789/510215Objective: The relationship between weight status, adenotonsillar hypertrophy and obstructive sleep apnea (OSA) in children has not yet been well studied. As the sleep parameters may show a disparity in different weight statuses, this study examined the relationship between the data of over-night polysomnography and different weight statuses, as well as the impact of adenotonsillar hypertrophy on children with OSA. Methods: Children with sleep disturbances were recruited from our clinics. Standard physical examinations, history taking, lateral neck roentgenography, and full-night polysomnography were obtained. Children were divided into four groups based on the age-and gender-corrected body mass index (BMI): underweight, normal weight, overweight and obese. An adenoidal/nasopharyngeal ratio of more than 0.67 was considered adenoidal hypertrophy. Tonsillar hypertrophy was defined as having Grade III tonsils or above. Results: From July 2006 to January 2009, 197 children were included in this study. Obese children had a significantly higher apnea-hypopnea index (AHI), obstructive apnea index and lower minimum oxygen saturation (MinSaO2) than those of the other groups. Underweight children had the second highest AHI. A negative correlation was also found between BMI z scores and MinSaO2 (r=-0.194; P=0.007). Children with tonsillar hypertrophy (P=0.001) were associated with a higher risk of having OSA. The risk of having OSA was significantly higher in obese children (P=0.001) and underweight children (P=0.043) than in those with a normal weight. Conclusion: Obesity, underweight status and tonsillar hypertrophy are associated with children having OSA, and obese children have a significantly higher risk than children with underweight status. ? 2012 Macmillan Publishers Limited All rights reserved.[SDGs]SDG3adenoid hypertrophy; adenotonsillar hypertrophy; adolescent; adult; anamnesis; apnea hypopnea index; apnea index; article; body mass; body weight; cervical spine radiography; child; correlation analysis; disease severity; female; human; major clinical study; male; obesity; oxygen saturation; physical examination; polysomnography; preschool child; priority journal; school child; sleep apnea syndrome; sleep disorder; underweight; Adenoids; Adolescent; Age Factors; Body Mass Index; Body Weight; Child; Child, Preschool; Female; Humans; Hypertrophy; Male; Overweight; Palatine Tonsil; Polysomnography; Risk Factors; Sleep Apnea, Obstructive; Taiwan; Thinnessjournal article10.1038/ijo.2012.5222703812-s2.0-84863726148