吳造中2018-07-122018-07-122003http://ntur.lib.ntu.edu.tw//handle/246246/22626依照本研究計畫的第一年目標，我們建立了新生小鼠的心臟細胞模型，並將利用此模型進行心臟肥厚機制的研究工作。此外我們也自健康的人血液中純化萃取低密度脂蛋白（LDL），經銅離子催化氧化後成為氧化態低密度脂蛋白（Oxidized LDL），用以瞭解氧化態低密度脂蛋白在冠狀動脈疾病發生時對心臟細胞直接的作用以及其作用機制。另外，TNF-a引發血管內皮細胞表現ICAM-1細胞黏著分子的細胞信息傳遞機制研究也在進行之中。As the planning goal of this first year’s project, we established the research model of neonatal rat cardiomyocytes for studying the mechanisms of cardiac hypertrophy. In addition, we also purified low-density lipoprotein (LDL) from healthy donors’ blood. We oxidized the LDL under the catalysis of copper ion and attempted to realize the acting mechanisms of oxidized LDL on cardiac myocytes when coronary artery disease occurred. Meanwhile, the signal transductional mechanisms of TNF-a induced ICAM-1 expression on endothelial cells were also under study.application/pdf247556 bytesapplication/pdfzh-TW國立臺灣大學醫學院一般醫學科journal articlehttp://ntur.lib.ntu.edu.tw/bitstream/246246/22626/1/912314B002283.pdf