Wang C.-C.CHEN-HUA LIULin C.-L.Wang P.-C.TAI-CHUNG TSENGLin H.H.JIA-HORNG KAO2021-09-042021-09-0420150929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943348732&doi=10.1016%2fj.jfma.2015.07.004&partnerID=40&md5=4c4be57e09f3a8a9c535de7875ee82e8https://scholars.lib.ntu.edu.tw/handle/123456789/581958Background/Purpose: Liver biopsy is the gold standard to determine the severity of hepatic fibrosis despite its risk and invasiveness. The aspartate aminotransferase/platelet ratio index (APRI) could noninvasively predict the severity of hepatic fibrosis in chronic hepatitis C (CHC) patients. Whether fibrosis index based on four factors (FIB-4) could better predict the severity of hepatic fibrosis than APRI in CHC patients remains inconclusive. Methods: This retrospective study enrolled 1473 CHC patients (784 men and 689 women) with liver biopsy and clinical data including age, aspartate aminotransferase, alanine aminotransferase, and platelet count. FIB-4 and APRI were calculated with a formula using the four clinical parameters. Hepatic fibrosis was staged using the Metavir classification system. Results: The areas under the receiver operating characteristics of FIB-4 for the diagnosis of significant fibrosis (? F2), advanced fibrosis (? F3), and cirrhosis (F4) were 0.816 [95% confidence interval (CI), 0.795-0.836], 0.827 (95% CI, 0.806-0.849), and 0.849 (95% CI, 0.830-0.867), respectively, compared with those of APRI-0.799 (95% CI, 0.778-0.819), 0.791 (95% CI, 0.770-0.812), and 0.802 (95% CI, 0.781-0.922). In addition, the areas under the receiver operating characteristics of FIB-4 were significantly greater than those of APRI for patients with advanced fibrosis and cirrhosis, respectively (p < 0.0001). Conclusion: FIB-4 could predict hepatic fibrosis in CHC patients. By adding two parameters (age and alanine aminotransferase), FIB-4 better predicts advanced fibrosis and cirrhosis than APRI in CHC patients. ? 2015.[SDGs]SDG3alanine aminotransferase; aspartate aminotransferase; alanine aminotransferase; aspartate aminotransferase; adult; age; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; aspartate aminotransferase platelet ratio index; chronic hepatitis C; clinical assessment tool; confidence interval; controlled study; diagnostic accuracy; diagnostic test accuracy study; disease classification; disease severity; female; fibrosis index based on four factors; genotype; Hepatitis C virus; human; human tissue; liver biopsy; liver cirrhosis; liver fibrosis; major clinical study; male; Metavir classification system; predictive value; receiver operating characteristic; retrospective study; sensitivity and specificity; statistical analysis; thrombocyte count; aged; biopsy; blood; chronic hepatitis C; complication; Hepacivirus; liver; liver cirrhosis; middle aged; pathology; severity of illness index; Taiwan; Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Biopsy; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Platelet Count; Retrospective Studies; ROC Curve; Severity of Illness Index; Taiwanjournal article10.1016/j.jfma.2015.07.004262791732-s2.0-84943348732