CHIN-HSIEN LINChen M.-L.Yu C.-Y.RUEY-MEEI WU2020-11-032020-11-0320130197-4580https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878940562&doi=10.1016%2fj.neurobiolaging.2013.04.005&partnerID=40&md5=7760d6a303e02558bcee04e5517603a0https://scholars.lib.ntu.edu.tw/handle/123456789/520074Recent genome-wide association studies of Parkinson's disease (PD) have identified the rs12456492 variant of the novel susceptibility loci, RIT2, as being associated with disease risk in a large white population. Studies among Asians are scarce. We genotyped RIT2 rs12456492 variant in a total of 1000 participants, comprising 500 patients with PD and 500 control subjects in a Taiwanese population. The frequency of GA/AA genotype was slightly higher in PD patients compared with controls, but was without statistical significance (odds ratio= 1.03, 95% confidence interval= 0.73-1.46, p= 0.86). We failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for PD in our population. ? 2013 Elsevier Inc.[SDGs]SDG3adenine; guanine; levodopa; adult; aged; article; Caucasian; cohort analysis; controlled study; disease association; dyskinesia; ethnic difference; ethnic group; female; gene; gene frequency; gene locus; genetic association; genetic risk; genetic susceptibility; genetic variability; genotype; heterozygote; human; major clinical study; male; motor dysfunction; Parkinson disease; population based case control study; population genetics; priority journal; risk assessment; RIT2 gene; Taiwanesejournal article10.1016/j.neurobiolaging.2013.04.0052-s2.0-84878940562