Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia

Lee, Ming TattMing TattLeeChiu, Yu-TingYu-TingChiuYU-CHUN CHIUHor, Chia ChunChia ChunHorLee, Hsin-JungHsin-JungLeeGuerrini, RemoRemoGuerriniCalo, GirolamoGirolamoCaloLIH-CHU CHIOU2020-05-062020-05-062020-01-091021-7770https://scholars.lib.ntu.edu.tw/handle/123456789/490891Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal links remain unclear. Here, we reveal an unprecedented sequential cascade involving these mediators in the lateral hypothalamus (LH) and ventrolateral periaqueductal gray (vlPAG) using a restraint stress-induced SIA model.enEndocannabinoid; Metabotropic glutamate receptor; Neuropeptide S; Orexin; Periaqueductal gray; Substance PNeuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesiajournal article10.1186/s12929-019-0590-1319150192-s2.0-85077704312WOS:000512121200001https://api.elsevier.com/content/abstract/scopus_id/85077704312