Tung Y.-C.Lin Y.-H.Chen H.-J.Chou S.-C.Cheng A.-C.Kalyanam N.Ho C.-T.MIN-HSIUNG PAN2019-07-112019-07-11201614203049https://scholars.lib.ntu.edu.tw/handle/123456789/413361Obesity is a global health concern. Piceatannol (Pic), an analog of resveratrol (Res), has many reported biological activities. In this study, we investigated the anti-obesity effect of Pic in a high-fat diet (HFD)-induced obese animal model. The results showed that Pic significantly reduced mouse body weight in a dose-dependent manner without affecting food intake. Serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) levels, and blood glucose (GLU) were significantly lowered in Pic-treated groups. Pic significantly decreased the weight of liver, spleen, perigonadal and retroperitoneal fat compared with the HFD group. Pic significantly reduced the adipocyte cell size of perigonadal fat and decreased the weight of liver. Pic-treated mice showed higher phosphorylated adenosine 50-monophosphate-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase (pACC) protein levels and decreased protein levels of CCAAT/enhancer-binding protein C/EBP, peroxisome proliferator-activated receptor PPAR and fatty acid synthase (FAS), resulting in decreased lipid accumulation in adipocytes and the liver. Pic altered the composition of the gut microbiota by increasing Firmicutes and Lactobacillus and decreasing Bacteroidetes compared with the HFD group. Collectively, these results suggest that Pic may be a candidate for obesity treatment. ? 2016 by the authors.AMPKC57BL/6Gut microbiotaHigh-fat dietObesityPiceatannol[SDGs]SDG33,3',4,5'-tetrahydroxystilbene; antiobesity agent; cholesterol; high density lipoprotein; low density lipoprotein; stilbene derivative; adipogenesis; adverse effects; animal; blood; body weight; C57BL mouse; chemically induced; disease model; dose response; drug effects; eating; gene expression regulation; intestine flora; lipid diet; metabolism; mouse; obesity; organ size; Adipogenesis; Animals; Anti-Obesity Agents; Body Weight; Cholesterol; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Gastrointestinal Microbiome; Gene Expression Regulation; Lipoproteins, HDL; Lipoproteins, LDL; Mice; Mice, Inbred C57BL; Obesity; Organ Size; Stilbenesjournal article10.3390/molecules21111419https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994026520&doi=10.3390%2fmolecules21111419&partnerID=40&md5=ad26bce304ca674ec9d10ec600d030a32-s2.0-84994026520https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994026520&doi=10.3390%2fmolecules21111419&partnerID=40&md5=ad26bce304ca674ec9d10ec600d030a3