2024-8-12024-12-02https://scholars.lib.ntu.edu.tw/handle/123456789/723440本計畫將透過了解NF2 突變於具有EGFR或ALK陽性之非小細胞肺癌患的發生頻率以及其如何影響下游訊息傳導路徑與驅動基因標靶藥物治療效果,找到標靶藥物新的抗藥機轉以及進一步的治療策略,以克服標靶藥物抗藥性與改善病人的預後。非小細胞肺癌NF2EGFRALK標靶治療抗藥性non-small-cell lung cancerNF2epidermal growth factor receptoranaplastic lymphoma kinasetargeted therapy resistanceThe Role of Nf2 Genomic Alterations in Non-Small-Cell Lung Cancer Patients with Egfr Mutations or Alk Fusions