Lin T.-H.Das K.Datta A.Leu W.-J.Hsiao H.-C.Lin C.-H.JIH-HWA GUHHuang J.-H.2021-06-022021-06-0220160022328Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85029621145&doi=10.1016%2fj.jorganchem.2016.01.029&partnerID=40&md5=7b0ce56e28aca4f85813abd798127975https://scholars.lib.ntu.edu.tw/handle/123456789/564770A series of keto-amine bidentate precursors 1–5, OCCH3CHCCH3NHR (where 1, R = C6H3-2,6-iPr2; 2, R = C6H2-2,4,6-Me3; 3, R = C6H4-2-tBu; 4, R = C6H4-2-OMe; 5, R = C6H4-2-OMe-5-Me) were synthesized and combined with [Ru(?6-p-cymene)Cl2]2 to generate the monomeric arene-Ru derivatives, [Ru(?6-p-cymene)(OCCH3CHCCH3NR)Cl] (where 6, R = C6H3-2,6-iPr2; 7, R = C6H2-2,4,6-Me3; 8, R = C6H4-2-tBu; 9, R = C6H4-2-OMe; 10, R = C6H4-2-OMe-5-Me) in moderate yield. The ruthenium derivatives effectively catalyzed the conversion rate in transfer hydrogenation of substituted acetophenone. The molecular structures of 2, 6–10 were determined by single crystal X-ray diffractometry in the solid state, revealing a four-coordination environment around the Ru atom. The potential anti-cancer activity of ruthenium derivatives against human hormone-refractory metastatic prostate cancer (HRMPC) cell lines was also studied. ? 2016 Elsevier B.V.Hormone-refractory prostate cancer; Keto-amine; Ruthenium; Transfer hydrogenation[SDGs]SDG3Cell culture; Chelation; Crystal atomic structure; Diseases; Hydrogenation; Ketones; Refractory materials; Ruthenium; Single crystals; Urology; X ray diffraction analysis; Acetophenones; Anticancer activities; Catalytic transfer hydrogenation; Conversion rates; Four coordination; Prostate cancers; Synthesis and characterizations; Transfer hydrogenations; Ruthenium compoundsjournal article10.1016/j.jorganchem.2016.01.0292-s2.0-85029621145