2015-01-012024-05-16https://scholars.lib.ntu.edu.tw/handle/123456789/667084摘要：本計畫探討正常人在自我運作中情緒認知互動的心理與大腦機制，以及自閉症患者在此一機制上的異常。本計畫將運用心理實驗、田野調查、腦部掃瞄以及動物實驗等方法探討個體在收錄外界訊息、形成語言表徵、產生自我意識、思考決策判斷、進行社會互動等不同歷程上，情緒認知互動之機制。第一個子計畫利用數理模型與腦部興奮影像研究人類辨識日常生活與觀看戲劇時臉部表情的神經心理機制。第二個子計畫透過比較中文與其他語言中有關情緒的隱喻，探討人類如何利用言語表徵情緒以及個人的身體反應在表徵自我與他人情緒中所扮演的角色。第三個子計畫以認知神經心理學實驗探討自我意識的產生與在不同狀態下變化的情形。第四個子計畫利用酬賞敏感異常的基因轉殖鼠進行反應選擇作業，探討情緒影響決策行為的神經機制，同時以腦部功能性掃瞄探討情緒因素影響人類在衝突下道德決策的神經機制。第五個子計畫探討腦中大鼠的同理行為與躲避反應社會學習以及嬰兒在社會互動下學習語音過程中，鏡像神經元或相關系統所扮演的角色。第六個子計畫探討自閉症患者自我異常現象從基因到社會行為的缺失，並以基因轉殖鼠形成病人異常行為的模型，以探討這些缺失的神經機制。這些研究的成果將有助於瞭解國人在特定社會文化情境下下大腦如何透過情緒與認知互動產生自我。<br> Abstract: The present project intends to study how interaction of cognition and emotion operates the self normally in an organism or aberrantly in patients with autistic spectrum disorders and the neural mechanisms underlying such normal and abnormal operations.. Studies will be designed to examine how emotion affects the operation of self by influencing the encoding of emotion information, formation of language representation, generation of self consciousness, making decision and judgment and enacting social relationship as well as how mal-functioning in these processes may contribute to the autistic symptoms. Cognitive experiments, field studies, and humans brain imaging as well as genetic, neurobiological and behavioral manipulations applied to animal models will be used to address these issues. Subproject 1 will study recognition of emotion expressed on human face in daily life and watching drama through brain imaging, computational and behavioral approaches. Subproject 2 will investigate how Madarin represents emotion in metaphors through an embodiment perspective. Subproject 3 will design behavior and fMRI experiments to test a theory on the self concept concerning the body and mental ownership in human under normal and altered states of consciousness as well as in autistic patients. Subproject 4 will study how emotion affects choice decision in transgenic mice with altered sensitivity to reward or punishment, and also how emotion influences moral decision bearing conflict of interest between self and others and the brain circuitry subserveing this effect. Subproject 5 will study the roles of mirror- and anti-mirror typed neurons in empathy-like social interaction and social learning of avoidance responses in rats as well as the role of such neural operation in acquisition of phonetic perception via social interaction between infants and mothers in humans. Subproject 6 will study the pathology of autism ranging from genes to behavior by delineating genetic correlates of different symptoms and endophenotypes in cognitive and emotion functions; gene knock-out mice will be used to study the neurobiological basis of aberrant behavior modeling various autistic symptoms. Findings from these studies are expected to shed lights on how self is construed and operated in the brain through interaction of emotion and cognition under our specific cultural context.認知情緒自我自閉症神經機制Cognitionemotionselfautismand neural mechanism